AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity

AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity

Inflammasomes are critical sensors that convey cellular stress and pathogen presence to the immune system by activating inflammatory caspases and cytokines such as IL-1β. The nature of endogenous stress signals that activate inflammasomes remains unclear. Here we show that an inhibitor of the HIV as...

Descripció completa

Dades bibliogràfiques
Autors principals:	Di Micco, A, Frera, G, Lugrin, J, Jamilloux, Y, Hsu, E, Tardivel, A, De Gassart, A, Zaffalon, L, Bujisic, B, Siegert, S, Quadroni, M, Broz, P, Henry, T, Hrycyna, C, Martinon, F
Format:	Journal article
Idioma:	English
Publicat:	National Academy of Sciences 2016

Ítems similars

Taking AIM at Influenza: The Role of the AIM2 Inflammasome
per: Dianne W. Xu, et al.
Publicat: (2024-09-01)

The aspartyl protease DDI2 drives adaptation to proteasome inhibition in multiple myeloma
per: Mélanie Op, et al.
Publicat: (2022-05-01)

The Role of AIM2 Inflammasome in Knee Osteoarthritis
per: Yang J, et al.
Publicat: (2022-11-01)

Roles of AIM2 Gene and AIM2 Inflammasome in the Pathogenesis and Treatment of Psoriasis
per: Jieyi Wang, et al.
Publicat: (2022-09-01)

Inflammasomes in Host Defense and Autoimmunity
per: Petr Broz
Publicat: (2016-12-01)

Activation and Pharmacological Regulation of Inflammasomes
per: Chen Chen, et al.
Publicat: (2022-07-01)

Detection of ASC Oligomerization by Western Blotting
per: Jérôme Lugrin, et al.
Publicat: (2017-05-01)

The protease DDI2 regulates NRF1 activation in response to cadmium toxicity
per: Sérgio T. Ribeiro, et al.
Publicat: (2022-10-01)

The AIM2 inflammasome is activated in astrocytes during the late phase of EAE
per: William E. Barclay, et al.
Publicat: (2022-04-01)

Role of the AIM2 Inflammasome in Cancer: Potential Therapeutic Strategies
per: Chiara Colarusso, et al.
Publicat: (2025-02-01)

Mitochondrial ROS potentiates indirect activation of the AIM2 inflammasome
per: Deborah D Crane, et al.
Publicat: (2014-08-01)

Pharmacological Inhibitors of the NLRP3 Inflammasome
per: Ayesha Zahid, et al.
Publicat: (2019-10-01)

COVID-19: lipid disruption is pushing the envelope
per: Garret A. FitzGerald
Publicat: (2022-07-01)

AIM2-inflammasome role in systemic lupus erythematous and rheumatoid arthritis
per: E. E. Uresti-Rivera, et al.
Publicat: (2022-09-01)

AIM2 Inflammasome's First Decade of Discovery: Focus on Oral Diseases
per: Lufei Wang, et al.
Publicat: (2020-08-01)

ER-trafficking triggers NRF1 ubiquitination to promote its proteolytic activation
per: Claire Chavarria, et al.
Publicat: (2023-10-01)

Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation
per: Qian Yin, et al.
Publicat: (2013-07-01)

Assembly mechanism of the inflammasome sensor AIM2 revealed by single molecule analysis
per: Meenakshi Sharma, et al.
Publicat: (2023-12-01)

Discovery of an inhibitor of DNA-driven inflammation that preferentially targets the AIM2 inflammasome
per: Jack P. Green, et al.
Publicat: (2023-05-01)

Tyrosine Dephosphorylation of ASC Modulates the Activation of the NLRP3 and AIM2 Inflammasomes
per: Bezaleel Mambwe, et al.
Publicat: (2019-07-01)

AIM2 inflammasome activation benefits the therapeutic effect of BCG in bladder carcinoma
per: Houhong Zhou, et al.
Publicat: (2022-10-01)

The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury
per: Hu, Bo, et al.
Publicat: (2018)

Pharmacological intervention of curcumin via the NLRP3 inflammasome in ischemic stroke
per: Xiaoxue Du, et al.
Publicat: (2023-10-01)

Cytoplasmic DNA and AIM2 inflammasome in RA: where they come from and where they go?
per: Conghui Xu, et al.
Publicat: (2024-10-01)

PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation
per: Min Xie, et al.
Publicat: (2016-10-01)

Shikonin Suppresses NLRP3 and AIM2 Inflammasomes by Direct Inhibition of Caspase-1.
per: Jernej Zorman, et al.
Publicat: (2016-01-01)

Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome
per: Li-Qiu Wang, et al.
Publicat: (2021-05-01)

AIM2 Engages Active but Unprocessed Caspase-1 to Induce Noncanonical Activation of the NLRP3 Inflammasome
per: Larissa D. Cunha, et al.
Publicat: (2017-07-01)

Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death
per: Laura E Sanman, et al.
Publicat: (2016-03-01)

Dual Engagement of the NLRP3 and AIM2 Inflammasomes by Plasmodium-Derived Hemozoin and DNA during Malaria
per: Parisa Kalantari, et al.
Publicat: (2014-01-01)

The mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors
per: Xiaoyan Zhan, et al.
Publicat: (2023-01-01)

Therapeutic Potential of Pharmacological Targeting NLRP3 Inflammasome Complex in Cancer
per: Gulcin Tezcan, et al.
Publicat: (2021-02-01)

The recombinant BCG ΔureC::hly vaccine targets the AIM2 Inflammasome to induce autophagy and inflammation
per: Saiga, H, et al.
Publicat: (2014)

The impact of AIM2 inflammasome-induced pyroptosis on acute gouty arthritis and asymptomatic hyperuricemia patients
per: Jiyan Chu, et al.
Publicat: (2024-07-01)

A novel role of AIM2 inflammasome-mediated pyroptosis in radiofrequency ablation of hepatocellular carcinoma
per: Feifan He, et al.
Publicat: (2024-11-01)

Artemisia Extract Suppresses NLRP3 and AIM2 Inflammasome Activation by Inhibition of ASC Phosphorylation
per: Su-Bin Kwak, et al.
Publicat: (2018-01-01)

TUDCA alleviates atherosclerosis by inhibiting AIM2 inflammasome and enhancing cholesterol efflux capacity in macrophage
per: Xuyang Wang, et al.
Publicat: (2024-06-01)

Correction: Shikonin Suppresses NLRP3 and AIM2 Inflammasomes by Direct Inhibition of Caspase-1.
per: Jernej Zorman, et al.
Publicat: (2016-01-01)

Effects of serum-clot contact time on second-trimester prenatal screening markers and their stability in serum
per: Bujišić Nada
Publicat: (2010-01-01)

Breaking barriers: noncanonical inflammasome executes blood–brain barrier disruption
per: Martin Dichgans, et al.
Publicat: (2024-08-01)