Hypoxia and hormone-mediated pathways converge at the histone demethylase KDM4B in cancer.
Hormones play an important role in pathophysiology. The hormone receptors, such as estrogen receptor alpha and androgen receptor in breast cancer and prostate cancer, are critical to cancer cell proliferation and tumor growth. In this review we focused on the cross-talk between hormone and hypoxia p...
| Main Authors: | , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
MDPI
2018
|
| _version_ | 1797059975183335424 |
|---|---|
| author | Yang, J Harris, A Davidoff, A |
| author_facet | Yang, J Harris, A Davidoff, A |
| author_sort | Yang, J |
| collection | OXFORD |
| description | Hormones play an important role in pathophysiology. The hormone receptors, such as estrogen receptor alpha and androgen receptor in breast cancer and prostate cancer, are critical to cancer cell proliferation and tumor growth. In this review we focused on the cross-talk between hormone and hypoxia pathways, particularly in breast cancer. We delineated a novel signaling pathway from estrogen receptor to hypoxia-inducible factor 1, and discussed the role of this pathway in endocrine therapy resistance. Further, we discussed the estrogen and hypoxia pathways converging at histone demethylase KDM4B, an important epigenetic modifier in cancer. |
| first_indexed | 2024-03-06T20:11:13Z |
| format | Journal article |
| id | oxford-uuid:2a9f4c4d-d6b8-4514-88c3-7b09b51b1dfe |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:11:13Z |
| publishDate | 2018 |
| publisher | MDPI |
| record_format | dspace |
| spelling | oxford-uuid:2a9f4c4d-d6b8-4514-88c3-7b09b51b1dfe2022-03-26T12:26:08ZHypoxia and hormone-mediated pathways converge at the histone demethylase KDM4B in cancer.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2a9f4c4d-d6b8-4514-88c3-7b09b51b1dfeEnglishSymplectic Elements at OxfordMDPI2018Yang, JHarris, ADavidoff, AHormones play an important role in pathophysiology. The hormone receptors, such as estrogen receptor alpha and androgen receptor in breast cancer and prostate cancer, are critical to cancer cell proliferation and tumor growth. In this review we focused on the cross-talk between hormone and hypoxia pathways, particularly in breast cancer. We delineated a novel signaling pathway from estrogen receptor to hypoxia-inducible factor 1, and discussed the role of this pathway in endocrine therapy resistance. Further, we discussed the estrogen and hypoxia pathways converging at histone demethylase KDM4B, an important epigenetic modifier in cancer. |
| spellingShingle | Yang, J Harris, A Davidoff, A Hypoxia and hormone-mediated pathways converge at the histone demethylase KDM4B in cancer. |
| title | Hypoxia and hormone-mediated pathways converge at the histone demethylase KDM4B in cancer. |
| title_full | Hypoxia and hormone-mediated pathways converge at the histone demethylase KDM4B in cancer. |
| title_fullStr | Hypoxia and hormone-mediated pathways converge at the histone demethylase KDM4B in cancer. |
| title_full_unstemmed | Hypoxia and hormone-mediated pathways converge at the histone demethylase KDM4B in cancer. |
| title_short | Hypoxia and hormone-mediated pathways converge at the histone demethylase KDM4B in cancer. |
| title_sort | hypoxia and hormone mediated pathways converge at the histone demethylase kdm4b in cancer |
| work_keys_str_mv | AT yangj hypoxiaandhormonemediatedpathwaysconvergeatthehistonedemethylasekdm4bincancer AT harrisa hypoxiaandhormonemediatedpathwaysconvergeatthehistonedemethylasekdm4bincancer AT davidoffa hypoxiaandhormonemediatedpathwaysconvergeatthehistonedemethylasekdm4bincancer |