Global analysis of DNA methylation variation in adipose tissue from twins reveals links to disease-associated variants in distal regulatory elements.

Global analysis of DNA methylation variation in adipose tissue from twins reveals links to disease-associated variants in distal regulatory elements.

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Epigenetic modifications such as DNA methylation play a key role in gene regulation and disease susceptibility. However, little is known about the genome-wide frequency, localization, and function of methylation variation and how it is regulated by genetic and environmental factors. We utilized the...

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Hlavní autoři: Grundberg, E, Meduri, E, Sandling, J, Hedman, A, Keildson, S, Buil, A, Busche, S, Yuan, W, Nisbet, J, Sekowska, M, Wilk, A, Barrett, A, Small, K, Ge, B, Caron, M, Shin, S, Lathrop, M, Dermitzakis, E, McCarthy, M, Spector, T, Bell, J, Deloukas, P
Médium: Journal article
Jazyk:English
Vydáno: 2013

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