Phenotyping REM OSA by means of peripheral arterial tone-based home sleep apnea testing and polysomnography: a critical assessment the sensitivity and specificity of both methods
The clinical relevance of rapid eye movement sleep-related obstructive sleep apnea (REM OSA) is supported by its associated adverse health outcomes and impact on optimal treatment strategies. To date, no assessment of REM OSA phenotyping performance has been conducted for any type of sleep testing t...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Wiley
2021
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| _version_ | 1826310278539640832 |
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| author | Massie, F van Pee, B Vits, S Verbraecken, J Bergmann, J |
| author_facet | Massie, F van Pee, B Vits, S Verbraecken, J Bergmann, J |
| author_sort | Massie, F |
| collection | OXFORD |
| description | The clinical relevance of rapid eye movement sleep-related obstructive sleep apnea (REM
OSA) is supported by its associated adverse health outcomes and impact on optimal treatment
strategies. To date, no assessment of REM OSA phenotyping performance has been conducted
for any type of sleep testing technology. The objective of this study was to assess this for
polysomnography (PSG) and a peripheral arterial tone-based home sleep apnea test (PAT
HSAT).
In a dataset comprising 261 participants, the sensitivity and specificity of the agreement on
REM OSA phenotyping was assessed for two independent scorings of PSG and
synchronously administered PAT HSAT.
The sensitivity and specificity of REM OSA phenotyping were 0.87 and 0.89 respectively for
the PSG inter-scorer comparison, and 0.68 and 0.97 for PAT HSAT on a single-night basis,
using the conventional minimum required REM sleep time of 30 minutes.
PSG-based REM OSA phenotyping was found to be sensitive and specific even for a singlenight testing protocol. PAT-based REM OSA phenotyping showed a lower sensitivity but a
slightly higher specificity compared to PSG. In order to increase performance and
conclusiveness of PAT-based REM OSA phenotyping, a multi-night protocol of 2 to 5 nights
could be considered.
Finally, the minimum required REM sleep time could be lowered from the conventional 30
minutes to 15 minutes without significantly lowering REM OSA phenotyping sensitivity and
specificity while increasing the level of phenotyping conclusiveness. |
| first_indexed | 2024-03-07T07:49:36Z |
| format | Journal article |
| id | oxford-uuid:2aa4718a-37e2-40a8-bac1-ab086bcfe384 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:49:36Z |
| publishDate | 2021 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:2aa4718a-37e2-40a8-bac1-ab086bcfe3842023-07-05T09:03:05ZPhenotyping REM OSA by means of peripheral arterial tone-based home sleep apnea testing and polysomnography: a critical assessment the sensitivity and specificity of both methodsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2aa4718a-37e2-40a8-bac1-ab086bcfe384EnglishSymplectic ElementsWiley2021Massie, Fvan Pee, BVits, SVerbraecken, JBergmann, JThe clinical relevance of rapid eye movement sleep-related obstructive sleep apnea (REM OSA) is supported by its associated adverse health outcomes and impact on optimal treatment strategies. To date, no assessment of REM OSA phenotyping performance has been conducted for any type of sleep testing technology. The objective of this study was to assess this for polysomnography (PSG) and a peripheral arterial tone-based home sleep apnea test (PAT HSAT). In a dataset comprising 261 participants, the sensitivity and specificity of the agreement on REM OSA phenotyping was assessed for two independent scorings of PSG and synchronously administered PAT HSAT. The sensitivity and specificity of REM OSA phenotyping were 0.87 and 0.89 respectively for the PSG inter-scorer comparison, and 0.68 and 0.97 for PAT HSAT on a single-night basis, using the conventional minimum required REM sleep time of 30 minutes. PSG-based REM OSA phenotyping was found to be sensitive and specific even for a singlenight testing protocol. PAT-based REM OSA phenotyping showed a lower sensitivity but a slightly higher specificity compared to PSG. In order to increase performance and conclusiveness of PAT-based REM OSA phenotyping, a multi-night protocol of 2 to 5 nights could be considered. Finally, the minimum required REM sleep time could be lowered from the conventional 30 minutes to 15 minutes without significantly lowering REM OSA phenotyping sensitivity and specificity while increasing the level of phenotyping conclusiveness. |
| spellingShingle | Massie, F van Pee, B Vits, S Verbraecken, J Bergmann, J Phenotyping REM OSA by means of peripheral arterial tone-based home sleep apnea testing and polysomnography: a critical assessment the sensitivity and specificity of both methods |
| title | Phenotyping REM OSA by means of peripheral arterial tone-based home sleep apnea testing and polysomnography: a critical assessment the sensitivity and specificity of both methods |
| title_full | Phenotyping REM OSA by means of peripheral arterial tone-based home sleep apnea testing and polysomnography: a critical assessment the sensitivity and specificity of both methods |
| title_fullStr | Phenotyping REM OSA by means of peripheral arterial tone-based home sleep apnea testing and polysomnography: a critical assessment the sensitivity and specificity of both methods |
| title_full_unstemmed | Phenotyping REM OSA by means of peripheral arterial tone-based home sleep apnea testing and polysomnography: a critical assessment the sensitivity and specificity of both methods |
| title_short | Phenotyping REM OSA by means of peripheral arterial tone-based home sleep apnea testing and polysomnography: a critical assessment the sensitivity and specificity of both methods |
| title_sort | phenotyping rem osa by means of peripheral arterial tone based home sleep apnea testing and polysomnography a critical assessment the sensitivity and specificity of both methods |
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