HLA-D/DR expression on epithelial cells: the finger on the trigger?
The findings we have described here show a clear association between epithelial HLA-D/DR expression and autoimmunity. Furthermore, the ability of class II+ thyrocytes to present both exogenous antigens and autoantigens indicates an active role for these HLA-D/DR molecules in autoimmune pathogenesis....
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1986
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| _version_ | 1797060009704554496 |
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| author | Todd, I Londei, M Pujol-Borrell, R Mirakian, R Feldmann, M Bottazzo, G |
| author_facet | Todd, I Londei, M Pujol-Borrell, R Mirakian, R Feldmann, M Bottazzo, G |
| author_sort | Todd, I |
| collection | OXFORD |
| description | The findings we have described here show a clear association between epithelial HLA-D/DR expression and autoimmunity. Furthermore, the ability of class II+ thyrocytes to present both exogenous antigens and autoantigens indicates an active role for these HLA-D/DR molecules in autoimmune pathogenesis. IFN-gamma is capable of inducing HLA-D/DR expression by thyroid epithelium, but a number of observations suggest the involvement of other inducers as well. Overall, we conclude that epithelial class II expression very probably plays a key role in the propagation and also in possibly the initiation of autoimmune attack. This is in accord with the proposal of a more general relationship between inappropriate or excessive class II expression and pathogenesis. |
| first_indexed | 2024-03-06T20:11:43Z |
| format | Journal article |
| id | oxford-uuid:2acda096-0737-4054-a227-c2ad136fbf28 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:11:43Z |
| publishDate | 1986 |
| record_format | dspace |
| spelling | oxford-uuid:2acda096-0737-4054-a227-c2ad136fbf282022-03-26T12:27:09ZHLA-D/DR expression on epithelial cells: the finger on the trigger?Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2acda096-0737-4054-a227-c2ad136fbf28EnglishSymplectic Elements at Oxford1986Todd, ILondei, MPujol-Borrell, RMirakian, RFeldmann, MBottazzo, GThe findings we have described here show a clear association between epithelial HLA-D/DR expression and autoimmunity. Furthermore, the ability of class II+ thyrocytes to present both exogenous antigens and autoantigens indicates an active role for these HLA-D/DR molecules in autoimmune pathogenesis. IFN-gamma is capable of inducing HLA-D/DR expression by thyroid epithelium, but a number of observations suggest the involvement of other inducers as well. Overall, we conclude that epithelial class II expression very probably plays a key role in the propagation and also in possibly the initiation of autoimmune attack. This is in accord with the proposal of a more general relationship between inappropriate or excessive class II expression and pathogenesis. |
| spellingShingle | Todd, I Londei, M Pujol-Borrell, R Mirakian, R Feldmann, M Bottazzo, G HLA-D/DR expression on epithelial cells: the finger on the trigger? |
| title | HLA-D/DR expression on epithelial cells: the finger on the trigger? |
| title_full | HLA-D/DR expression on epithelial cells: the finger on the trigger? |
| title_fullStr | HLA-D/DR expression on epithelial cells: the finger on the trigger? |
| title_full_unstemmed | HLA-D/DR expression on epithelial cells: the finger on the trigger? |
| title_short | HLA-D/DR expression on epithelial cells: the finger on the trigger? |
| title_sort | hla d dr expression on epithelial cells the finger on the trigger |
| work_keys_str_mv | AT toddi hladdrexpressiononepithelialcellsthefingeronthetrigger AT londeim hladdrexpressiononepithelialcellsthefingeronthetrigger AT pujolborrellr hladdrexpressiononepithelialcellsthefingeronthetrigger AT mirakianr hladdrexpressiononepithelialcellsthefingeronthetrigger AT feldmannm hladdrexpressiononepithelialcellsthefingeronthetrigger AT bottazzog hladdrexpressiononepithelialcellsthefingeronthetrigger |