Design of inhibitors of glycogen phosphorylase: a study of alpha- and beta-C-glucosides and 1-thio-beta-D-glucose compounds.

Design of inhibitors of glycogen phosphorylase: a study of alpha- and beta-C-glucosides and 1-thio-beta-D-glucose compounds.

alpha-D-Glucose is a weak inhibitor of glycogen phosphorylase b (Ki = 1.7 mM) and acts as a physiological regulator of hepatic glycogen metabolism. Glucose binds to phosphorylase at the catalytic site and results in a conformational change that stabilizes the inactive T state of the enzyme, promotin...

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Bibliographic Details
Main Authors:	Watson, K, Mitchell, E, Johnson, L, Son, J, Bichard, C, Orchard, MG, Fleet, G, Oikonomakos, N, Leonidas, D, Kontou, M
Format:	Journal article
Language:	English
Published:	1994

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