Crossover study of immunoglobulin replacement therapy in patients with low-grade B-cell tumors.
A randomized crossover study of prophylactic immunoglobulin (IgG) therapy was performed in patients with chronic lymphocytic leukaemia (CLL) or non-Hodgkin's lymphoma (NHL). Twelve patients with hypogammaglobulinemia or a history of recurrent infections received infusions of IgG or placebo intr...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1989
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| _version_ | 1797060077207683072 |
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| author | Griffiths, H Brennan, V Lea, J Bunch, C Lee, M Chapel, H |
| author_facet | Griffiths, H Brennan, V Lea, J Bunch, C Lee, M Chapel, H |
| author_sort | Griffiths, H |
| collection | OXFORD |
| description | A randomized crossover study of prophylactic immunoglobulin (IgG) therapy was performed in patients with chronic lymphocytic leukaemia (CLL) or non-Hodgkin's lymphoma (NHL). Twelve patients with hypogammaglobulinemia or a history of recurrent infections received infusions of IgG or placebo intravenously (IV) every 3 weeks for 1 year. They were then switched to the alternative preparation for another year. The number of serious bacterial infections was significantly less (P = .001; Mainland's cross-over method) in the months in which patients received IgG. Serious bacterial infections showed a trend to be associated with an IgG level less than 6.4 g/L (P = .046; Fisher's exact test). |
| first_indexed | 2024-03-06T20:12:33Z |
| format | Journal article |
| id | oxford-uuid:2b0e6a92-9206-49da-bc5c-2bc031f5f26e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:12:33Z |
| publishDate | 1989 |
| record_format | dspace |
| spelling | oxford-uuid:2b0e6a92-9206-49da-bc5c-2bc031f5f26e2022-03-26T12:28:39ZCrossover study of immunoglobulin replacement therapy in patients with low-grade B-cell tumors.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2b0e6a92-9206-49da-bc5c-2bc031f5f26eEnglishSymplectic Elements at Oxford1989Griffiths, HBrennan, VLea, JBunch, CLee, MChapel, HA randomized crossover study of prophylactic immunoglobulin (IgG) therapy was performed in patients with chronic lymphocytic leukaemia (CLL) or non-Hodgkin's lymphoma (NHL). Twelve patients with hypogammaglobulinemia or a history of recurrent infections received infusions of IgG or placebo intravenously (IV) every 3 weeks for 1 year. They were then switched to the alternative preparation for another year. The number of serious bacterial infections was significantly less (P = .001; Mainland's cross-over method) in the months in which patients received IgG. Serious bacterial infections showed a trend to be associated with an IgG level less than 6.4 g/L (P = .046; Fisher's exact test). |
| spellingShingle | Griffiths, H Brennan, V Lea, J Bunch, C Lee, M Chapel, H Crossover study of immunoglobulin replacement therapy in patients with low-grade B-cell tumors. |
| title | Crossover study of immunoglobulin replacement therapy in patients with low-grade B-cell tumors. |
| title_full | Crossover study of immunoglobulin replacement therapy in patients with low-grade B-cell tumors. |
| title_fullStr | Crossover study of immunoglobulin replacement therapy in patients with low-grade B-cell tumors. |
| title_full_unstemmed | Crossover study of immunoglobulin replacement therapy in patients with low-grade B-cell tumors. |
| title_short | Crossover study of immunoglobulin replacement therapy in patients with low-grade B-cell tumors. |
| title_sort | crossover study of immunoglobulin replacement therapy in patients with low grade b cell tumors |
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