Decreased plasma tryptophan levels in major depression.
Total plasma tryptophan was significantly lower in 12 depressed patients than in 12 normal controls. The ratio of total tryptophan to neutral amino acids was also decreased in the depressed patients suggesting that tryptophan availability to the brain might be reduced. There was no correlation betwe...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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1989
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| _version_ | 1797060083458244608 |
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| author | Cowen, P Parry-Billings, M Newsholme, E |
| author_facet | Cowen, P Parry-Billings, M Newsholme, E |
| author_sort | Cowen, P |
| collection | OXFORD |
| description | Total plasma tryptophan was significantly lower in 12 depressed patients than in 12 normal controls. The ratio of total tryptophan to neutral amino acids was also decreased in the depressed patients suggesting that tryptophan availability to the brain might be reduced. There was no correlation between basal tryptophan concentrations in the depressed subjects and the subsequent neuroendocrine response to intravenous tryptophan. |
| first_indexed | 2024-03-06T20:12:38Z |
| format | Journal article |
| id | oxford-uuid:2b15ba3d-a8be-43a5-b9f9-1f538bd63bb8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:12:38Z |
| publishDate | 1989 |
| record_format | dspace |
| spelling | oxford-uuid:2b15ba3d-a8be-43a5-b9f9-1f538bd63bb82022-03-26T12:28:51ZDecreased plasma tryptophan levels in major depression.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2b15ba3d-a8be-43a5-b9f9-1f538bd63bb8EnglishSymplectic Elements at Oxford1989Cowen, PParry-Billings, MNewsholme, ETotal plasma tryptophan was significantly lower in 12 depressed patients than in 12 normal controls. The ratio of total tryptophan to neutral amino acids was also decreased in the depressed patients suggesting that tryptophan availability to the brain might be reduced. There was no correlation between basal tryptophan concentrations in the depressed subjects and the subsequent neuroendocrine response to intravenous tryptophan. |
| spellingShingle | Cowen, P Parry-Billings, M Newsholme, E Decreased plasma tryptophan levels in major depression. |
| title | Decreased plasma tryptophan levels in major depression. |
| title_full | Decreased plasma tryptophan levels in major depression. |
| title_fullStr | Decreased plasma tryptophan levels in major depression. |
| title_full_unstemmed | Decreased plasma tryptophan levels in major depression. |
| title_short | Decreased plasma tryptophan levels in major depression. |
| title_sort | decreased plasma tryptophan levels in major depression |
| work_keys_str_mv | AT cowenp decreasedplasmatryptophanlevelsinmajordepression AT parrybillingsm decreasedplasmatryptophanlevelsinmajordepression AT newsholmee decreasedplasmatryptophanlevelsinmajordepression |