Epigenetic therapy induces transcription of inverted SINEs and ADAR1 dependency

Epigenetic therapy induces transcription of inverted SINEs and ADAR1 dependency

Cancer therapies that target epigenetic repressors can mediate their effects by activating retroelements within the human genome. Retroelement transcripts can form double-stranded RNA (dsRNA) that activates the MDA5 pattern recognition receptor. This state of viral mimicry leads to loss of cancer ce...

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Bibliographic Details
Main Authors: Mehdipour, P, Marhon, SA, Ettayebi, I, Chakravarthy, A, Hosseini, A, Wang, Y, de Castro, FA, Loo Yau, H, Ishak, C, Abelson, S, O’Brien, CA, De Carvalho, DD
Format: Journal article
Language:English
Published: Springer Nature 2020

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