Phase II trial of combretastatin A4 phosphate, carboplatin, and paclitaxel in patients with platinum-resistant ovarian cancer.

BACKGROUND: A previous dose-escalation trial of the vascular disrupting agent combretastatin A4 phosphate (CA4P) given before carboplatin, paclitaxel, or both showed responses in 7 of 18 patients with relapsed ovarian cancer. PATIENTS AND METHODS: Patients with ovarian cancer that had relapsed and...

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Bibliographic Details
Main Authors: Zweifel, M, Jayson, G, Reed, N, Osborne, R, Hassan, B, Ledermann, J, Shreeves, G, Poupard, L, Lu, S, Balkissoon, J, Chaplin, D, Rustin, G
Format: Journal article
Language:English
Published: 2011