Opiate peptides control growth hormone through a cholinergic mechanism in man.
Opiate peptides are known to elevate circulating GH in man, and data in other animals suggest that acetylcholine may be involved. We have administered the long-acting met-enkephalin analogue DAMME to 6 normal males, and have shown that the resulting elevation in GH is blocked by the specific choline...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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1983
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| _version_ | 1826264757814951936 |
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| author | Delitala, G Grossman, A Besser, G |
| author_facet | Delitala, G Grossman, A Besser, G |
| author_sort | Delitala, G |
| collection | OXFORD |
| description | Opiate peptides are known to elevate circulating GH in man, and data in other animals suggest that acetylcholine may be involved. We have administered the long-acting met-enkephalin analogue DAMME to 6 normal males, and have shown that the resulting elevation in GH is blocked by the specific cholinergic antagonist, pirenzepine. It seems likely that a cholinergic mechanism may interact with opiate-induced changes in GH in man. |
| first_indexed | 2024-03-06T20:12:59Z |
| format | Journal article |
| id | oxford-uuid:2b35a9c5-13a5-4ba2-a816-423cc024a51b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:12:59Z |
| publishDate | 1983 |
| record_format | dspace |
| spelling | oxford-uuid:2b35a9c5-13a5-4ba2-a816-423cc024a51b2022-03-26T12:29:34ZOpiate peptides control growth hormone through a cholinergic mechanism in man.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2b35a9c5-13a5-4ba2-a816-423cc024a51bEnglishSymplectic Elements at Oxford1983Delitala, GGrossman, ABesser, GOpiate peptides are known to elevate circulating GH in man, and data in other animals suggest that acetylcholine may be involved. We have administered the long-acting met-enkephalin analogue DAMME to 6 normal males, and have shown that the resulting elevation in GH is blocked by the specific cholinergic antagonist, pirenzepine. It seems likely that a cholinergic mechanism may interact with opiate-induced changes in GH in man. |
| spellingShingle | Delitala, G Grossman, A Besser, G Opiate peptides control growth hormone through a cholinergic mechanism in man. |
| title | Opiate peptides control growth hormone through a cholinergic mechanism in man. |
| title_full | Opiate peptides control growth hormone through a cholinergic mechanism in man. |
| title_fullStr | Opiate peptides control growth hormone through a cholinergic mechanism in man. |
| title_full_unstemmed | Opiate peptides control growth hormone through a cholinergic mechanism in man. |
| title_short | Opiate peptides control growth hormone through a cholinergic mechanism in man. |
| title_sort | opiate peptides control growth hormone through a cholinergic mechanism in man |
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