Identification of self through two-dimensional chemistry and synapses.
Cells in the immune and nervous systems communicate through informational synapses. The two-dimensional chemistry underlying the process of synapse formation is beginning to be explored using fluorescence imaging and mechanical techniques. Early analysis of two-dimensional kinetic rates (k(on) and k...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2001
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| _version_ | 1797060132293574656 |
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| author | Dustin, M Bromley, S Davis, M Zhu, C |
| author_facet | Dustin, M Bromley, S Davis, M Zhu, C |
| author_sort | Dustin, M |
| collection | OXFORD |
| description | Cells in the immune and nervous systems communicate through informational synapses. The two-dimensional chemistry underlying the process of synapse formation is beginning to be explored using fluorescence imaging and mechanical techniques. Early analysis of two-dimensional kinetic rates (k(on) and k(off)) and equilibrium constants (K(d)) provides a number of biological insights. First, there are two regimes for adhesion-one disordered with slow k(on) and the other self-ordered with 10(4)-fold faster k(on). Despite huge variation in two-dimensional k(on), the two-dimensional k(off) is like k(off) in solution, and two-dimensional k(off) is more closely related to intrinsic properties of the interaction than the two-dimensional k(on). Thus difference in k(off) can be used to set signaling thresholds. Early signaling complexes are compartmentalized to generate synergistic signaling domains. Immune antigen receptor components have a role in neural synapse editing. This suggests significant parallels in informational synapse formation based on common two-dimensional chemistry and signaling strategies. |
| first_indexed | 2024-03-06T20:13:14Z |
| format | Journal article |
| id | oxford-uuid:2b4b4406-07de-42e3-b2d2-4db7780af1a8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:13:14Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | oxford-uuid:2b4b4406-07de-42e3-b2d2-4db7780af1a82022-03-26T12:30:00ZIdentification of self through two-dimensional chemistry and synapses.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2b4b4406-07de-42e3-b2d2-4db7780af1a8EnglishSymplectic Elements at Oxford2001Dustin, MBromley, SDavis, MZhu, CCells in the immune and nervous systems communicate through informational synapses. The two-dimensional chemistry underlying the process of synapse formation is beginning to be explored using fluorescence imaging and mechanical techniques. Early analysis of two-dimensional kinetic rates (k(on) and k(off)) and equilibrium constants (K(d)) provides a number of biological insights. First, there are two regimes for adhesion-one disordered with slow k(on) and the other self-ordered with 10(4)-fold faster k(on). Despite huge variation in two-dimensional k(on), the two-dimensional k(off) is like k(off) in solution, and two-dimensional k(off) is more closely related to intrinsic properties of the interaction than the two-dimensional k(on). Thus difference in k(off) can be used to set signaling thresholds. Early signaling complexes are compartmentalized to generate synergistic signaling domains. Immune antigen receptor components have a role in neural synapse editing. This suggests significant parallels in informational synapse formation based on common two-dimensional chemistry and signaling strategies. |
| spellingShingle | Dustin, M Bromley, S Davis, M Zhu, C Identification of self through two-dimensional chemistry and synapses. |
| title | Identification of self through two-dimensional chemistry and synapses. |
| title_full | Identification of self through two-dimensional chemistry and synapses. |
| title_fullStr | Identification of self through two-dimensional chemistry and synapses. |
| title_full_unstemmed | Identification of self through two-dimensional chemistry and synapses. |
| title_short | Identification of self through two-dimensional chemistry and synapses. |
| title_sort | identification of self through two dimensional chemistry and synapses |
| work_keys_str_mv | AT dustinm identificationofselfthroughtwodimensionalchemistryandsynapses AT bromleys identificationofselfthroughtwodimensionalchemistryandsynapses AT davism identificationofselfthroughtwodimensionalchemistryandsynapses AT zhuc identificationofselfthroughtwodimensionalchemistryandsynapses |