Measuring macroscopic brain connections in vivo.
Decades of detailed anatomical tracer studies in non-human animals point to a rich and complex organization of long-range white matter connections in the brain. State-of-the art in vivo imaging techniques are striving to achieve a similar level of detail in humans, but multiple technical factors can...
| Autori principali: | , , , , |
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| Natura: | Journal article |
| Lingua: | English |
| Pubblicazione: |
Nature Publishing Group
2015
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| _version_ | 1826264774083608576 |
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| author | Jbabdi, S Sotiropoulos, S Haber, S Van Essen, D Behrens, T |
| author_facet | Jbabdi, S Sotiropoulos, S Haber, S Van Essen, D Behrens, T |
| author_sort | Jbabdi, S |
| collection | OXFORD |
| description | Decades of detailed anatomical tracer studies in non-human animals point to a rich and complex organization of long-range white matter connections in the brain. State-of-the art in vivo imaging techniques are striving to achieve a similar level of detail in humans, but multiple technical factors can limit their sensitivity and fidelity. In this review, we mostly focus on magnetic resonance imaging of the brain. We highlight some of the key challenges in analyzing and interpreting in vivo connectomics data, particularly in relation to what is known from classical neuroanatomy in laboratory animals. We further illustrate that, despite the challenges, in vivo imaging methods can be very powerful and provide information on connections that is not available by any other means. |
| first_indexed | 2024-03-06T20:13:15Z |
| format | Journal article |
| id | oxford-uuid:2b4b79e8-bfa4-4add-8f7b-31b22635fafd |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:13:15Z |
| publishDate | 2015 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:2b4b79e8-bfa4-4add-8f7b-31b22635fafd2022-03-26T12:30:03ZMeasuring macroscopic brain connections in vivo.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2b4b79e8-bfa4-4add-8f7b-31b22635fafdEnglishSymplectic Elements at OxfordNature Publishing Group2015Jbabdi, SSotiropoulos, SHaber, SVan Essen, DBehrens, TDecades of detailed anatomical tracer studies in non-human animals point to a rich and complex organization of long-range white matter connections in the brain. State-of-the art in vivo imaging techniques are striving to achieve a similar level of detail in humans, but multiple technical factors can limit their sensitivity and fidelity. In this review, we mostly focus on magnetic resonance imaging of the brain. We highlight some of the key challenges in analyzing and interpreting in vivo connectomics data, particularly in relation to what is known from classical neuroanatomy in laboratory animals. We further illustrate that, despite the challenges, in vivo imaging methods can be very powerful and provide information on connections that is not available by any other means. |
| spellingShingle | Jbabdi, S Sotiropoulos, S Haber, S Van Essen, D Behrens, T Measuring macroscopic brain connections in vivo. |
| title | Measuring macroscopic brain connections in vivo. |
| title_full | Measuring macroscopic brain connections in vivo. |
| title_fullStr | Measuring macroscopic brain connections in vivo. |
| title_full_unstemmed | Measuring macroscopic brain connections in vivo. |
| title_short | Measuring macroscopic brain connections in vivo. |
| title_sort | measuring macroscopic brain connections in vivo |
| work_keys_str_mv | AT jbabdis measuringmacroscopicbrainconnectionsinvivo AT sotiropouloss measuringmacroscopicbrainconnectionsinvivo AT habers measuringmacroscopicbrainconnectionsinvivo AT vanessend measuringmacroscopicbrainconnectionsinvivo AT behrenst measuringmacroscopicbrainconnectionsinvivo |