The systemic response to brain injury and disease
The idea that the brain is immunologically privileged and displays an atypical leukocyte recruitment profile following injury has influenced our ideas about how signals might be carried between brain and the periphery. For many, this has encouraged a cerebrocentric view of immunological responses to...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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2012
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| _version_ | 1826264775887159296 |
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| author | Anthony, D Couch, Y Losey, P Evans, M |
| author_facet | Anthony, D Couch, Y Losey, P Evans, M |
| author_sort | Anthony, D |
| collection | OXFORD |
| description | The idea that the brain is immunologically privileged and displays an atypical leukocyte recruitment profile following injury has influenced our ideas about how signals might be carried between brain and the periphery. For many, this has encouraged a cerebrocentric view of immunological responses to CNS injury, with little reference to the potential contribution from other organs. However, it is clear that bidirectional pathways between the brain and the peripheral immune system are important in the pathogenesis of CNS disease. In recent years, we have begun to understand the signals that are carried to the periphery and discovered new functions for known chemokines, made by the liver in response to brain injury, as important regulators of the CNS inflammatory response. © 2011. |
| first_indexed | 2024-03-06T20:13:16Z |
| format | Journal article |
| id | oxford-uuid:2b4f0db8-af6a-498e-b963-e6bfabf4f9c9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:13:16Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:2b4f0db8-af6a-498e-b963-e6bfabf4f9c92022-03-26T12:30:04ZThe systemic response to brain injury and diseaseJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2b4f0db8-af6a-498e-b963-e6bfabf4f9c9EnglishSymplectic Elements at Oxford2012Anthony, DCouch, YLosey, PEvans, MThe idea that the brain is immunologically privileged and displays an atypical leukocyte recruitment profile following injury has influenced our ideas about how signals might be carried between brain and the periphery. For many, this has encouraged a cerebrocentric view of immunological responses to CNS injury, with little reference to the potential contribution from other organs. However, it is clear that bidirectional pathways between the brain and the peripheral immune system are important in the pathogenesis of CNS disease. In recent years, we have begun to understand the signals that are carried to the periphery and discovered new functions for known chemokines, made by the liver in response to brain injury, as important regulators of the CNS inflammatory response. © 2011. |
| spellingShingle | Anthony, D Couch, Y Losey, P Evans, M The systemic response to brain injury and disease |
| title | The systemic response to brain injury and disease |
| title_full | The systemic response to brain injury and disease |
| title_fullStr | The systemic response to brain injury and disease |
| title_full_unstemmed | The systemic response to brain injury and disease |
| title_short | The systemic response to brain injury and disease |
| title_sort | systemic response to brain injury and disease |
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