The molecular sociology of the cell.
Proteomic studies have yielded detailed lists of the proteins present in a cell. Comparatively little is known, however, about how these proteins interact and are spatially arranged within the 'functional modules' of the cell: that is, the 'molecular sociology' of the cell. This...
| Main Authors: | , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2007
|
| _version_ | 1797060196866981888 |
|---|---|
| author | Robinson, C Sali, A Baumeister, W |
| author_facet | Robinson, C Sali, A Baumeister, W |
| author_sort | Robinson, C |
| collection | OXFORD |
| description | Proteomic studies have yielded detailed lists of the proteins present in a cell. Comparatively little is known, however, about how these proteins interact and are spatially arranged within the 'functional modules' of the cell: that is, the 'molecular sociology' of the cell. This gap is now being bridged by using emerging experimental techniques, such as mass spectrometry of complexes and single-particle cryo-electron microscopy, to complement traditional biochemical and biophysical methods. With the development of integrative computational methods to exploit the data obtained, such hybrid approaches will uncover the molecular architectures, and perhaps even atomic models, of many protein complexes. With these structures in hand, researchers will be poised to use cryo-electron tomography to view protein complexes in action within cells, providing unprecedented insights into protein-interaction networks. |
| first_indexed | 2024-03-06T20:13:55Z |
| format | Journal article |
| id | oxford-uuid:2b81c3d9-a554-4c01-86df-9a56babe5de8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:13:55Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:2b81c3d9-a554-4c01-86df-9a56babe5de82022-03-26T12:31:16ZThe molecular sociology of the cell.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2b81c3d9-a554-4c01-86df-9a56babe5de8EnglishSymplectic Elements at Oxford2007Robinson, CSali, ABaumeister, WProteomic studies have yielded detailed lists of the proteins present in a cell. Comparatively little is known, however, about how these proteins interact and are spatially arranged within the 'functional modules' of the cell: that is, the 'molecular sociology' of the cell. This gap is now being bridged by using emerging experimental techniques, such as mass spectrometry of complexes and single-particle cryo-electron microscopy, to complement traditional biochemical and biophysical methods. With the development of integrative computational methods to exploit the data obtained, such hybrid approaches will uncover the molecular architectures, and perhaps even atomic models, of many protein complexes. With these structures in hand, researchers will be poised to use cryo-electron tomography to view protein complexes in action within cells, providing unprecedented insights into protein-interaction networks. |
| spellingShingle | Robinson, C Sali, A Baumeister, W The molecular sociology of the cell. |
| title | The molecular sociology of the cell. |
| title_full | The molecular sociology of the cell. |
| title_fullStr | The molecular sociology of the cell. |
| title_full_unstemmed | The molecular sociology of the cell. |
| title_short | The molecular sociology of the cell. |
| title_sort | molecular sociology of the cell |
| work_keys_str_mv | AT robinsonc themolecularsociologyofthecell AT salia themolecularsociologyofthecell AT baumeisterw themolecularsociologyofthecell AT robinsonc molecularsociologyofthecell AT salia molecularsociologyofthecell AT baumeisterw molecularsociologyofthecell |