A high-resolution consensus linkage map of the rat, integrating radiation hybrid and genetic maps.
We have constructed a high-resolution consensus genetic map of the rat in a single large intercross, which integrates 747 framework markers and 687 positions of our whole-genome radiation hybrid (RH) map of the rat. We selected 136 new gene markers from the GenBank database and assigned them either...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2001
|
| _version_ | 1797060203119640576 |
|---|---|
| author | Bihoreau, M Sebag-Montefiore, L Godfrey, R Wallis, R Brown, J Danoy, P Collins, S Rouard, M Kaisaki, P Lathrop, M Gauguier, D |
| author_facet | Bihoreau, M Sebag-Montefiore, L Godfrey, R Wallis, R Brown, J Danoy, P Collins, S Rouard, M Kaisaki, P Lathrop, M Gauguier, D |
| author_sort | Bihoreau, M |
| collection | OXFORD |
| description | We have constructed a high-resolution consensus genetic map of the rat in a single large intercross, which integrates 747 framework markers and 687 positions of our whole-genome radiation hybrid (RH) map of the rat. We selected 136 new gene markers from the GenBank database and assigned them either genetically or physically to rat chromosomes to evaluate the accuracy of the integrated linkage-RH maps in the localization of new markers and to enrich existing comparative mapping data. These markers and 631 D-Got- markers, which are physically mapped but still uncharacterized for evidence of polymorphism, were tested for allele variations in a panel of 16 rat strains commonly used in genetic studies. The consensus linkage map constructed in the GK x BN cross now comprises 1620 markers of various origins, defining 840 resolved genetic positions with an average spacing of 2.2 cM between adjacent loci, and includes 407 gene markers. This whole-genome genetic map will contribute to the advancement of genetic studies in the rat by incorporating gene/EST maps, physical mapping information, and sequence data generated in rat and other mammalian species into genetic intervals harboring disease susceptibility loci identified in rat models of human genetic disorders. |
| first_indexed | 2024-03-06T20:14:01Z |
| format | Journal article |
| id | oxford-uuid:2b88a977-2bc0-4e82-b402-6f78b626c7ca |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:14:01Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | oxford-uuid:2b88a977-2bc0-4e82-b402-6f78b626c7ca2022-03-26T12:31:28ZA high-resolution consensus linkage map of the rat, integrating radiation hybrid and genetic maps.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2b88a977-2bc0-4e82-b402-6f78b626c7caEnglishSymplectic Elements at Oxford2001Bihoreau, MSebag-Montefiore, LGodfrey, RWallis, RBrown, JDanoy, PCollins, SRouard, MKaisaki, PLathrop, MGauguier, DWe have constructed a high-resolution consensus genetic map of the rat in a single large intercross, which integrates 747 framework markers and 687 positions of our whole-genome radiation hybrid (RH) map of the rat. We selected 136 new gene markers from the GenBank database and assigned them either genetically or physically to rat chromosomes to evaluate the accuracy of the integrated linkage-RH maps in the localization of new markers and to enrich existing comparative mapping data. These markers and 631 D-Got- markers, which are physically mapped but still uncharacterized for evidence of polymorphism, were tested for allele variations in a panel of 16 rat strains commonly used in genetic studies. The consensus linkage map constructed in the GK x BN cross now comprises 1620 markers of various origins, defining 840 resolved genetic positions with an average spacing of 2.2 cM between adjacent loci, and includes 407 gene markers. This whole-genome genetic map will contribute to the advancement of genetic studies in the rat by incorporating gene/EST maps, physical mapping information, and sequence data generated in rat and other mammalian species into genetic intervals harboring disease susceptibility loci identified in rat models of human genetic disorders. |
| spellingShingle | Bihoreau, M Sebag-Montefiore, L Godfrey, R Wallis, R Brown, J Danoy, P Collins, S Rouard, M Kaisaki, P Lathrop, M Gauguier, D A high-resolution consensus linkage map of the rat, integrating radiation hybrid and genetic maps. |
| title | A high-resolution consensus linkage map of the rat, integrating radiation hybrid and genetic maps. |
| title_full | A high-resolution consensus linkage map of the rat, integrating radiation hybrid and genetic maps. |
| title_fullStr | A high-resolution consensus linkage map of the rat, integrating radiation hybrid and genetic maps. |
| title_full_unstemmed | A high-resolution consensus linkage map of the rat, integrating radiation hybrid and genetic maps. |
| title_short | A high-resolution consensus linkage map of the rat, integrating radiation hybrid and genetic maps. |
| title_sort | high resolution consensus linkage map of the rat integrating radiation hybrid and genetic maps |
| work_keys_str_mv | AT bihoreaum ahighresolutionconsensuslinkagemapoftheratintegratingradiationhybridandgeneticmaps AT sebagmontefiorel ahighresolutionconsensuslinkagemapoftheratintegratingradiationhybridandgeneticmaps AT godfreyr ahighresolutionconsensuslinkagemapoftheratintegratingradiationhybridandgeneticmaps AT wallisr ahighresolutionconsensuslinkagemapoftheratintegratingradiationhybridandgeneticmaps AT brownj ahighresolutionconsensuslinkagemapoftheratintegratingradiationhybridandgeneticmaps AT danoyp ahighresolutionconsensuslinkagemapoftheratintegratingradiationhybridandgeneticmaps AT collinss ahighresolutionconsensuslinkagemapoftheratintegratingradiationhybridandgeneticmaps AT rouardm ahighresolutionconsensuslinkagemapoftheratintegratingradiationhybridandgeneticmaps AT kaisakip ahighresolutionconsensuslinkagemapoftheratintegratingradiationhybridandgeneticmaps AT lathropm ahighresolutionconsensuslinkagemapoftheratintegratingradiationhybridandgeneticmaps AT gauguierd ahighresolutionconsensuslinkagemapoftheratintegratingradiationhybridandgeneticmaps AT bihoreaum highresolutionconsensuslinkagemapoftheratintegratingradiationhybridandgeneticmaps AT sebagmontefiorel highresolutionconsensuslinkagemapoftheratintegratingradiationhybridandgeneticmaps AT godfreyr highresolutionconsensuslinkagemapoftheratintegratingradiationhybridandgeneticmaps AT wallisr highresolutionconsensuslinkagemapoftheratintegratingradiationhybridandgeneticmaps AT brownj highresolutionconsensuslinkagemapoftheratintegratingradiationhybridandgeneticmaps AT danoyp highresolutionconsensuslinkagemapoftheratintegratingradiationhybridandgeneticmaps AT collinss highresolutionconsensuslinkagemapoftheratintegratingradiationhybridandgeneticmaps AT rouardm highresolutionconsensuslinkagemapoftheratintegratingradiationhybridandgeneticmaps AT kaisakip highresolutionconsensuslinkagemapoftheratintegratingradiationhybridandgeneticmaps AT lathropm highresolutionconsensuslinkagemapoftheratintegratingradiationhybridandgeneticmaps AT gauguierd highresolutionconsensuslinkagemapoftheratintegratingradiationhybridandgeneticmaps |