Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease

Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease

ARH3/ADPRHL2 and PARG are the primary enzymes reversing ADP-ribosylation in vertebrates, yet their functions in vivo remain unclear. ARH3 is the only hydrolase able to remove serine-linked mono(ADP-ribose) (MAR) but is much less efficient than PARG against poly(ADP-ribose) (PAR) chains in&a...

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Bibliographic Details
Main Authors:	Prokhorova, E, Agnew, T, Wondisford, AR, Tellier, M, Kaminski, N, Beijer, D, Holder, J, Groslambert, J, Suskiewicz, MJ, Zhu, K, Reber, JM, Krassnig, SC, Palazzo, L, Murphy, S, Nielsen, ML, Mangerich, A, Ahel, D, Baets, J, O'Sullivan, RJ, Ahel, I
Format:	Journal article
Language:	English
Published:	Cell Press 2021

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