Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents.

Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents.

The HIF (hypoxia-inducible factor) hydroxylases [PHDs or EGLNs (prolyl hydroxylases), which in humans are PHD isoforms 1-3, and FIH (factor inhibiting HIF)] regulate HIF levels and activity. These enzymes are Fe(II)/2-oxoglutarate-dependent oxygenases, many of which are stimulated by ascorbate. We h...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Flashman, E, Davies, S, Yeoh, K, Schofield, C
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	2010

Eitemau Tebyg

Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases
gan: Chan, M, et al.
Cyhoeddwyd: (2016)

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
gan: Chowdhury, R, et al.
Cyhoeddwyd: (2013)

Structural, biochemical and inhibition studies on hypoxia-inducible factor (HIF) prolyl hydroxylases
gan: Lippl, K
Cyhoeddwyd: (2018)

Inhibition of hypoxia inducible factor (HIF) hydroxylases
gan: Conejo-Garcia, A, et al.
Cyhoeddwyd: (2005)

Neuroprotective Effect of HIF Prolyl Hydroxylase Inhibition in an In Vitro Hypoxia Model
gan: Maria Savyuk, et al.
Cyhoeddwyd: (2020-07-01)

Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen.
gan: Flashman, E, et al.
Cyhoeddwyd: (2010)

Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen.
gan: Flashman, E, et al.
Cyhoeddwyd: (2010)

Studies on the inhibition of human hypoxia inducible factor (HIF) hydroxylases
gan: Yeoh, KK
Cyhoeddwyd: (2012)

Regulation of HIF: prolyl hydroxylases.
gan: Stolze, I, et al.
Cyhoeddwyd: (2006)

Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases.
gan: Chowdhury, R, et al.
Cyhoeddwyd: (2009)

Signalling hypoxia by HIF hydroxylases.
gan: Schofield, C, et al.
Cyhoeddwyd: (2005)

Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1)
gan: Chowdhury, R, et al.
Cyhoeddwyd: (2011)

Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1).
gan: Chowdhury, R, et al.
Cyhoeddwyd: (2011)

Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase, and is sensitive to off target inhibition by prolyl hydroxylase domain inhibitors that stabilise Hypoxia Inducible Factor
gan: Kiriakidis, S, et al.
Cyhoeddwyd: (2017)

BIOL 56-ESI-MS studies on prolyl hydroxylase domain 2
gan: Mecinovic, J, et al.
Cyhoeddwyd: (2008)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
gan: Chowdhury, R, et al.
Cyhoeddwyd: (2016)

HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice.
gan: Chen, R, et al.
Cyhoeddwyd: (2014)

HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice
gan: Chen, R, et al.
Cyhoeddwyd: (2014)

Studies on the substrate selectivity of the hypoxia-inducible factor prolyl hydroxylase 2 catalytic domain
gan: Abboud, M, et al.
Cyhoeddwyd: (2018)

Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2.
gan: Hewitson, K, et al.
Cyhoeddwyd: (2007)

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.
gan: Mole, D, et al.
Cyhoeddwyd: (2003)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
gan: Rasheduzzaman Chowdhury, et al.
Cyhoeddwyd: (2016-08-01)

Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen.
gan: Tarhonskaya, H, et al.
Cyhoeddwyd: (2014)

The use of dioxygen by HIF prolyl hydroxylase (PHD1).
gan: McNeill, L, et al.
Cyhoeddwyd: (2002)

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.
gan: Schlemminger, I, et al.
Cyhoeddwyd: (2003)

Inhibition studies on hypoxia-inducible factor (HIF) hydroxylases
gan: Chan, M
Cyhoeddwyd: (2014)

Structural basis of prolyl hydroxylase domain inhibition by Molidustat
gan: Figg, WD, et al.
Cyhoeddwyd: (2021)

Inhibition of a viral prolyl hydroxylase
gan: Langley, G, et al.
Cyhoeddwyd: (2019)

Inhibition of HIF-prolyl hydroxylases improves healing of intestinal anastomoses
gan: Moritz J. Strowitzki, et al.
Cyhoeddwyd: (2021-04-01)

Kinetic investigations of the oxygen entry pathway of the hypoxia-inducible factor (HIF) prolyl hydroxylase 2
gan: Kearney, L
Cyhoeddwyd: (2015)

Molecular and Cellular Mechanisms of HIF Prolyl Hydroxylase inhibitors in Clinical Trials
gan: Yeh, TL, et al.
Cyhoeddwyd: (2017)

Synthesis And Characterization Of Potential Human Hypoxia Inducible Factor (Hif) Prolyl Hydroxylase Domain 2 (Phd-2) Inhibitors
gan: Toh, Lee Roy
Cyhoeddwyd: (2021)

Tissue expression and functional insights into HIF prolyl hydroxylase domain enzymes
gan: Wijeyekoon, JB
Cyhoeddwyd: (2013)

Use of mass spectrometry to probe the nucleophilicity of cysteinyl residues of prolyl hydroxylase domain 2.
gan: Mecinović, J, et al.
Cyhoeddwyd: (2009)

2-oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2
gan: Abboud, M, et al.
Cyhoeddwyd: (2018)

Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases.
gan: Lancaster, D, et al.
Cyhoeddwyd: (2004)

Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model
gan: Singh, A, et al.
Cyhoeddwyd: (2020)

Hypoxia inducible factor prolyl hydroxylases in inflammatory bowel disease
gan: Jie Lun, et al.
Cyhoeddwyd: (2023-05-01)

Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing.
gan: Webb, J, et al.
Cyhoeddwyd: (2009)

Determination and comparison of specific activity of the HIF-prolyl hydroxylases.
gan: Tuckerman, JR, et al.
Cyhoeddwyd: (2004)