Practical approaches for detecting selection in microbial genomes
Microbial genome evolution is shaped by a variety of selective pressures. Understanding how these processes occur can help to address important problems in microbiology by explaining observed differences in phenotypes, including virulence and resistance to antibiotics. Greater access to whole-genome...
| Egile Nagusiak: | , |
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| Formatua: | Journal article |
| Hizkuntza: | English |
| Argitaratua: |
Public Library of Science
2016
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| _version_ | 1826264870445645824 |
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| author | Hedge, J Wilson, D |
| author_facet | Hedge, J Wilson, D |
| author_sort | Hedge, J |
| collection | OXFORD |
| description | Microbial genome evolution is shaped by a variety of selective pressures. Understanding how these processes occur can help to address important problems in microbiology by explaining observed differences in phenotypes, including virulence and resistance to antibiotics. Greater access to whole-genome sequencing provides microbiologists with the opportunity to perform large-scale analyses of selection in novel settings, such as within individual hosts. This tutorial aims to guide researchers through the fundamentals underpinning popular methods for measuring selection in pathogens. These methods are transferable to a wide variety of organisms, and the exercises provided are designed for researchers with any level of programming experience. |
| first_indexed | 2024-03-06T20:14:48Z |
| format | Journal article |
| id | oxford-uuid:2bc4fb2d-df5f-498c-9926-1af7130b957e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:14:48Z |
| publishDate | 2016 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | oxford-uuid:2bc4fb2d-df5f-498c-9926-1af7130b957e2022-03-26T12:33:02ZPractical approaches for detecting selection in microbial genomesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2bc4fb2d-df5f-498c-9926-1af7130b957eEnglishSymplectic Elements at OxfordPublic Library of Science2016Hedge, JWilson, DMicrobial genome evolution is shaped by a variety of selective pressures. Understanding how these processes occur can help to address important problems in microbiology by explaining observed differences in phenotypes, including virulence and resistance to antibiotics. Greater access to whole-genome sequencing provides microbiologists with the opportunity to perform large-scale analyses of selection in novel settings, such as within individual hosts. This tutorial aims to guide researchers through the fundamentals underpinning popular methods for measuring selection in pathogens. These methods are transferable to a wide variety of organisms, and the exercises provided are designed for researchers with any level of programming experience. |
| spellingShingle | Hedge, J Wilson, D Practical approaches for detecting selection in microbial genomes |
| title | Practical approaches for detecting selection in microbial genomes |
| title_full | Practical approaches for detecting selection in microbial genomes |
| title_fullStr | Practical approaches for detecting selection in microbial genomes |
| title_full_unstemmed | Practical approaches for detecting selection in microbial genomes |
| title_short | Practical approaches for detecting selection in microbial genomes |
| title_sort | practical approaches for detecting selection in microbial genomes |
| work_keys_str_mv | AT hedgej practicalapproachesfordetectingselectioninmicrobialgenomes AT wilsond practicalapproachesfordetectingselectioninmicrobialgenomes |