Testing the super-enhancer concept
Many enhancers exist as clusters in the genome, which has led to the coining of the term ‘super-enhancer’. In this Viewpoint, five experts discuss our biological understanding of enhancer clusters, how we can responsibly study their functions, and their opinions on whether names for enhancer cluster...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Springer Nature
2021
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| _version_ | 1826312428037603328 |
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| author | Blobel, GA Higgs, DR Mitchell, JA Notani, D Young, RA |
| author_facet | Blobel, GA Higgs, DR Mitchell, JA Notani, D Young, RA |
| author_sort | Blobel, GA |
| collection | OXFORD |
| description | Many enhancers exist as clusters in the genome, which has led to the coining of the term ‘super-enhancer’. In this Viewpoint, five experts discuss our biological understanding of enhancer clusters, how we can responsibly study their functions, and their opinions on whether names for enhancer clusters are an informative reflection of their functional properties. They also provide their thoughts on key unanswered questions and future directions in the field. |
| first_indexed | 2024-03-07T08:28:48Z |
| format | Journal article |
| id | oxford-uuid:2bd353b5-c465-49ec-80cc-77b403e1a22f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T08:28:48Z |
| publishDate | 2021 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:2bd353b5-c465-49ec-80cc-77b403e1a22f2024-03-06T11:26:32ZTesting the super-enhancer conceptJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2bd353b5-c465-49ec-80cc-77b403e1a22fEnglishSymplectic ElementsSpringer Nature2021Blobel, GAHiggs, DRMitchell, JANotani, DYoung, RAMany enhancers exist as clusters in the genome, which has led to the coining of the term ‘super-enhancer’. In this Viewpoint, five experts discuss our biological understanding of enhancer clusters, how we can responsibly study their functions, and their opinions on whether names for enhancer clusters are an informative reflection of their functional properties. They also provide their thoughts on key unanswered questions and future directions in the field. |
| spellingShingle | Blobel, GA Higgs, DR Mitchell, JA Notani, D Young, RA Testing the super-enhancer concept |
| title | Testing the super-enhancer concept |
| title_full | Testing the super-enhancer concept |
| title_fullStr | Testing the super-enhancer concept |
| title_full_unstemmed | Testing the super-enhancer concept |
| title_short | Testing the super-enhancer concept |
| title_sort | testing the super enhancer concept |
| work_keys_str_mv | AT blobelga testingthesuperenhancerconcept AT higgsdr testingthesuperenhancerconcept AT mitchellja testingthesuperenhancerconcept AT notanid testingthesuperenhancerconcept AT youngra testingthesuperenhancerconcept |