CACNA1H antibodies associated with headache with neurological deficits and cerebrospinal fluid lymphocytosis (HaNDL).
BACKGROUND: Patients with the syndrome of headache with neurological deficits and lymphocytosis (HaNDL) typically present with recurrent and temporary attacks of neurological symptoms and cerebrospinal fluid lymphocytosis. AIM AND METHODS: To identify potential HaNDL-associated antibodies directed...
| Huvudupphovsmän: | , , , , , , , , , , , , , |
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| Materialtyp: | Journal article |
| Språk: | English |
| Publicerad: |
2013
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| _version_ | 1826264885197012992 |
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| author | Kürtüncü, M Kaya, D Zuliani, L Erdağ, E Içöz, S Uğurel, E Cavuş, F Ayşit, N Birişik, O Vincent, A Eraksoy, M Vural, B Akman-Demir, G Tüzün, E |
| author_facet | Kürtüncü, M Kaya, D Zuliani, L Erdağ, E Içöz, S Uğurel, E Cavuş, F Ayşit, N Birişik, O Vincent, A Eraksoy, M Vural, B Akman-Demir, G Tüzün, E |
| author_sort | Kürtüncü, M |
| collection | OXFORD |
| description | BACKGROUND: Patients with the syndrome of headache with neurological deficits and lymphocytosis (HaNDL) typically present with recurrent and temporary attacks of neurological symptoms and cerebrospinal fluid lymphocytosis. AIM AND METHODS: To identify potential HaNDL-associated antibodies directed against neuronal surface and/or synapse antigens, sera of four HaNDL patients and controls were screened with indirect immunohistochemistry, immunofluorescence, cell-based assay, radioimmunoassay, protein macroarray and enzyme-linked immunosorbent assay (ELISA). RESULTS: Although HaNDL sera did not yield antibodies to any of the well-characterized neuronal surface or synapse antigens, protein macroarray and ELISA studies showed high-titer antibodies to a subunit of the T-type voltage-gated calcium channel (VGCC), CACNA1H, in sera of two HaNDL patients. CONCLUSION: Our results support the notion that ion channel autoimmunity might at least partially contribute to HaNDL pathogenesis and occurrence of neurological symptoms. |
| first_indexed | 2024-03-06T20:15:02Z |
| format | Journal article |
| id | oxford-uuid:2bd9a0db-aef9-4860-9596-bd752d6ca69f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:15:02Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:2bd9a0db-aef9-4860-9596-bd752d6ca69f2022-03-26T12:33:34ZCACNA1H antibodies associated with headache with neurological deficits and cerebrospinal fluid lymphocytosis (HaNDL).Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2bd9a0db-aef9-4860-9596-bd752d6ca69fEnglishSymplectic Elements at Oxford2013Kürtüncü, MKaya, DZuliani, LErdağ, EIçöz, SUğurel, ECavuş, FAyşit, NBirişik, OVincent, AEraksoy, MVural, BAkman-Demir, GTüzün, E BACKGROUND: Patients with the syndrome of headache with neurological deficits and lymphocytosis (HaNDL) typically present with recurrent and temporary attacks of neurological symptoms and cerebrospinal fluid lymphocytosis. AIM AND METHODS: To identify potential HaNDL-associated antibodies directed against neuronal surface and/or synapse antigens, sera of four HaNDL patients and controls were screened with indirect immunohistochemistry, immunofluorescence, cell-based assay, radioimmunoassay, protein macroarray and enzyme-linked immunosorbent assay (ELISA). RESULTS: Although HaNDL sera did not yield antibodies to any of the well-characterized neuronal surface or synapse antigens, protein macroarray and ELISA studies showed high-titer antibodies to a subunit of the T-type voltage-gated calcium channel (VGCC), CACNA1H, in sera of two HaNDL patients. CONCLUSION: Our results support the notion that ion channel autoimmunity might at least partially contribute to HaNDL pathogenesis and occurrence of neurological symptoms. |
| spellingShingle | Kürtüncü, M Kaya, D Zuliani, L Erdağ, E Içöz, S Uğurel, E Cavuş, F Ayşit, N Birişik, O Vincent, A Eraksoy, M Vural, B Akman-Demir, G Tüzün, E CACNA1H antibodies associated with headache with neurological deficits and cerebrospinal fluid lymphocytosis (HaNDL). |
| title | CACNA1H antibodies associated with headache with neurological deficits and cerebrospinal fluid lymphocytosis (HaNDL). |
| title_full | CACNA1H antibodies associated with headache with neurological deficits and cerebrospinal fluid lymphocytosis (HaNDL). |
| title_fullStr | CACNA1H antibodies associated with headache with neurological deficits and cerebrospinal fluid lymphocytosis (HaNDL). |
| title_full_unstemmed | CACNA1H antibodies associated with headache with neurological deficits and cerebrospinal fluid lymphocytosis (HaNDL). |
| title_short | CACNA1H antibodies associated with headache with neurological deficits and cerebrospinal fluid lymphocytosis (HaNDL). |
| title_sort | cacna1h antibodies associated with headache with neurological deficits and cerebrospinal fluid lymphocytosis handl |
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