The class II phosphatidylinositol 3 kinase C2beta is required for the activation of the K+ channel KCa3.1 and CD4 T-cells.

The Ca(2+)-activated K(+) channel KCa3.1 is required for Ca(2+) influx and the subsequent activation of T-cells. We previously showed that nucleoside diphosphate kinase beta (NDPK-B), a mammalian histidine kinase, directly phosphorylates and activates KCa3.1 and is required for the activation of hum...

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Hlavní autoři:	Srivastava, S, Di, L, Zhdanova, O, Li, Z, Vardhana, S, Wan, Q, Yan, Y, Varma, R, Backer, J, Wulff, H, Dustin, M, Skolnik, E
Médium:	Journal article
Jazyk:	English
Vydáno:	2009

The class II phosphatidylinositol 3 kinase C2beta is required for the activation of the K+ channel KCa3.1 and CD4 T-cells.

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