Modeling damage complexity-dependent non-homologous end-joining repair pathway

Modeling damage complexity-dependent non-homologous end-joining repair pathway

Non-homologous end joining (NHEJ) is the dominant DNA double strand break (DSB) repair pathway and involves several repair proteins such as Ku, DNA-PKcs, and XRCC4. It has been experimentally shown that the choice of NHEJ proteins is determined by the complexity of DSB. In this paper, we built a mat...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Li, Y, Reynolds, P, O'Neill, P, Cucinotta, F
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	Public Library of Science 2014

Antzeko izenburuak

Biochemical kinetics model of DSB repair and induction of gamma-H2AX foci by non-homologous end joining.
nork: Cucinotta, F, et al.
Argitaratua: (2008)

Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining
nork: Ly, Peter, et al.
Argitaratua: (2018)

The roles of the human SETMAR (Metnase) protein in illegitimate DNA recombination and non-homologous end joining repair
nork: Tellier, M, et al.
Argitaratua: (2019)

IGF-1R inhibition enhances radiosensitivity and delays double-strand break repair by both non-homologous end-joining and homologous recombination.
nork: Chitnis, M, et al.
Argitaratua: (2014)

LINC complexes promote homologous recombination in part through inhibition of nonhomologous end joining
nork: Lawrence, Katherine S., et al.
Argitaratua: (2017)

Saccharomyces cerevisiae C1D is implicated in both non-homologous DNA end joining and homologous recombination.
nork: Erdemir, T, et al.
Argitaratua: (2002)

The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity
nork: Becker, JR, et al.
Argitaratua: (2018)

Interplay of two major repair pathways in the processing of complex double-strand DNA breaks.
nork: Dobbs, T, et al.
Argitaratua: (2008)

Use of near infrared femtosecond lasers as sub-micron radiation microbeam for cell DNA damage and repair studies.
nork: Botchway, S, et al.
Argitaratua: (2010)

Inhibition of double-strand break non-homologous end-joining by cisplatin adducts in human cell extracts.
nork: Diggle, C, et al.
Argitaratua: (2005)

Repair of oxidative base lesions within clustered DNA damage
nork: O'Neill, P, et al.
Argitaratua: (2002)

Multi-pathway DNA-repair reporters reveal competition between end-joining, single-strand annealing and homologous recombination at Cas9-induced DNA double-strand breaks
nork: van de Kooij, Bert, et al.
Argitaratua: (2023)

Shieldin and CST co-orchestrate DNA polymerase-dependent tailed-end joining reactions independently of 53BP1-governed repair pathway choice
nork: King, A, et al.
Argitaratua: (2024)

Spatiotemporal dynamics of DNA repair proteins following laser microbeam induced DNA damage - When is a DSB not a DSB?
nork: Reynolds, P, et al.
Argitaratua: (2013)

Spatiotemporal dynamics of DNA repair proteins following laser microbeam induced DNA damage - when is a DSB not a DSB?
nork: Reynolds, P, et al.
Argitaratua: (2013)

Participation of DNA-PKcs in DSB repair after exposure to high- and low-LET radiation.
nork: Anderson, J, et al.
Argitaratua: (2010)

The dynamics of Ku70/80 and DNA-PKcs at DSBs induced by ionizing radiation is dependent on the complexity of damage.
nork: Reynolds, P, et al.
Argitaratua: (2012)

Non-homologous end-joining partners in a helical dance: structural studies of XLF-XRCC4 interactions.
nork: Wu, Q, et al.
Argitaratua: (2011)

Biological consequences of potential repair intermediates of clustered base damage site in Escherichia coli.
nork: Shikazono, N, et al.
Argitaratua: (2009)

Delayed repair of radiation induced clustered DNA damage: Friend or foe?
nork: Eccles, L, et al.
Argitaratua: (2011)

Delayed repair of radiation induced clustered DNA damage: friend or foe?
nork: Eccles, L, et al.
Argitaratua: (2011)

A role for human homologous recombination factors in suppressing microhomology-mediated end joining.
nork: Ahrabi, S, et al.
Argitaratua: (2016)

Efficiency of repair of an abasic site within DNA clustered damage sites by mammalian cell nuclear extracts.
nork: Lomax, M, et al.
Argitaratua: (2004)

Human fetal/tumor metakaryotic stem cells: pangenomic homologous pairing and telomeric end-joining of chromatids
nork: Gostjeva, Elena V., et al.
Argitaratua: (2015)

8-OxoG retards the activity of the ligase III/XRCC1 complex during the repair of a single-strand break, when present within a clustered DNA damage site.
nork: Lomax, M, et al.
Argitaratua: (2004)

Screening for inhibitors of and novel proteins within the homologous recombination DNA repair pathway
nork: Kingham, G
Argitaratua: (2012)

The DNA damage checkpoint pathway promotes extensive resection and nucleotide synthesis to facilitate homologous recombination repair and genome stability in fission yeast.
nork: Blaikley, E, et al.
Argitaratua: (2014)

Hierarchy of lesion processing governs the repair, double-strand break formation and mutability of three-lesion clustered DNA damage.
nork: Eccles, L, et al.
Argitaratua: (2010)

Radiation-induced damage in DNA
nork: O'Neill, P
Argitaratua: (2001)

Base excision repair processing of abasic site/single-strand break lesions within clustered damage sites associated with XRCC1 deficiency.
nork: Mourgues, S, et al.
Argitaratua: (2007)

Radiation-induced damage migration in DNA: Base damage distribution
nork: O'Neill, P, et al.
Argitaratua: (2000)

5,6-Dihydrothymine impairs the base excision repair pathway of a closely opposed AP site or single-strand break.
nork: Byrne, S, et al.
Argitaratua: (2009)

DNA damage and radical reactions: Mechanistic aspects, formation in cells and repair studies
nork: Cadet, J, et al.
Argitaratua: (2008)

DNA double strand break repair in human bladder cancer is error prone and involves microhomology-associated end-joining.
nork: Bentley, J, et al.
Argitaratua: (2004)

ATM regulates a RASSF1A-dependent DNA damage response.
nork: Hamilton, G, et al.
Argitaratua: (2009)

Free radicals associated with DNA damage.
nork: Chatgilialoglu, C, et al.
Argitaratua: (2001)

Femtosecond near infrared laser microbeam technique for submicrometer point source for high-resolution cell DNA damage, signaling and repair studies
nork: Botchway, S, et al.
Argitaratua: (2006)

Structure of the helicase domain of DNA polymerase theta reveals a possible role in the microhomology-mediated end-joining pathway
nork: Newman, J, et al.
Argitaratua: (2015)

Novel Smad proteins localize to IR-induced double-strand breaks: interplay between TGFβ and ATM pathways.
nork: Wang, M, et al.
Argitaratua: (2013)

DNA damage and nonhomologous end joining in excitotoxicity: neuroprotective role of DNA-PKcs in kainic acid-induced seizures.
nork: Neema, M, et al.
Argitaratua: (2005)