Immunological biomarkers predict HIV-1 viral rebound after treatment interruption
Treatment of HIV-1 infection with antiretroviral therapy (ART) in the weeks following transmission may induce a state of 'post-treatment control' (PTC) in some patients, in whom viraemia remains undetectable when ART is stopped. Explaining PTC could help our understanding of the processes...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Nature Publishing Group
2015
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| _version_ | 1826264906808164352 |
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| author | Hurst, J Hoffmann, M Pace, M Williams, J Thornhill, J Hamlyn, E Meyerowitz, J Willberg, C Willberg, C Koelsch, K Robinson, N Brown, H Fisher, M Kinloch, S Cooper, D Schechter, M Tambussi, G Fidler, S Babiker, A Weber, J Kelleher, A Phillips, R Frater, A |
| author_facet | Hurst, J Hoffmann, M Pace, M Williams, J Thornhill, J Hamlyn, E Meyerowitz, J Willberg, C Willberg, C Koelsch, K Robinson, N Brown, H Fisher, M Kinloch, S Cooper, D Schechter, M Tambussi, G Fidler, S Babiker, A Weber, J Kelleher, A Phillips, R Frater, A |
| author_sort | Hurst, J |
| collection | OXFORD |
| description | Treatment of HIV-1 infection with antiretroviral therapy (ART) in the weeks following transmission may induce a state of 'post-treatment control' (PTC) in some patients, in whom viraemia remains undetectable when ART is stopped. Explaining PTC could help our understanding of the processes that maintain viral persistence. Here we show that immunological biomarkers can predict time to viral rebound after stopping ART by analysing data from a randomized study of primary HIV-1 infection incorporating a treatment interruption (TI) after 48 weeks of ART (the SPARTAC trial). T-cell exhaustion markers PD-1, Tim-3 and Lag-3 measured prior to ART strongly predict time to the return of viraemia. These data indicate that T-cell exhaustion markers may identify those latently infected cells with a higher proclivity to viral transcription. Our results may open new avenues for understanding the mechanisms underlying PTC, and eventually HIV-1 eradication. |
| first_indexed | 2024-03-06T20:15:23Z |
| format | Journal article |
| id | oxford-uuid:2bf87e1f-536d-40e0-b72c-4ada3fa0db94 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:15:23Z |
| publishDate | 2015 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:2bf87e1f-536d-40e0-b72c-4ada3fa0db942022-03-26T12:34:14ZImmunological biomarkers predict HIV-1 viral rebound after treatment interruptionJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2bf87e1f-536d-40e0-b72c-4ada3fa0db94EnglishSymplectic Elements at OxfordNature Publishing Group2015Hurst, JHoffmann, MPace, MWilliams, JThornhill, JHamlyn, EMeyerowitz, JWillberg, CWillberg, CKoelsch, KRobinson, NBrown, HFisher, MKinloch, SCooper, DSchechter, MTambussi, GFidler, SBabiker, AWeber, JKelleher, APhillips, RFrater, ATreatment of HIV-1 infection with antiretroviral therapy (ART) in the weeks following transmission may induce a state of 'post-treatment control' (PTC) in some patients, in whom viraemia remains undetectable when ART is stopped. Explaining PTC could help our understanding of the processes that maintain viral persistence. Here we show that immunological biomarkers can predict time to viral rebound after stopping ART by analysing data from a randomized study of primary HIV-1 infection incorporating a treatment interruption (TI) after 48 weeks of ART (the SPARTAC trial). T-cell exhaustion markers PD-1, Tim-3 and Lag-3 measured prior to ART strongly predict time to the return of viraemia. These data indicate that T-cell exhaustion markers may identify those latently infected cells with a higher proclivity to viral transcription. Our results may open new avenues for understanding the mechanisms underlying PTC, and eventually HIV-1 eradication. |
| spellingShingle | Hurst, J Hoffmann, M Pace, M Williams, J Thornhill, J Hamlyn, E Meyerowitz, J Willberg, C Willberg, C Koelsch, K Robinson, N Brown, H Fisher, M Kinloch, S Cooper, D Schechter, M Tambussi, G Fidler, S Babiker, A Weber, J Kelleher, A Phillips, R Frater, A Immunological biomarkers predict HIV-1 viral rebound after treatment interruption |
| title | Immunological biomarkers predict HIV-1 viral rebound after treatment interruption |
| title_full | Immunological biomarkers predict HIV-1 viral rebound after treatment interruption |
| title_fullStr | Immunological biomarkers predict HIV-1 viral rebound after treatment interruption |
| title_full_unstemmed | Immunological biomarkers predict HIV-1 viral rebound after treatment interruption |
| title_short | Immunological biomarkers predict HIV-1 viral rebound after treatment interruption |
| title_sort | immunological biomarkers predict hiv 1 viral rebound after treatment interruption |
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