Investigating D-lysine stereochemistry for epigenetic methylation, demethylation and recognition
Histone lysine methylation is regulated by Nε-methyltransferases, demethylases, and Nε-methyl lysine binding proteins. Thermodynamic, catalytic and computational studies were carried out to investigate the interaction of three epigenetic protein classes with synthetic histone substrates containing l...
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| Main Authors: |
Belle, R,
Al Temimi, A,
Kumar, K,
Pieters, B,
Tumber, A,
Dunford, J,
Johansson, C,
Oppermann, U,
Brown, T,
Schofield, C,
Hopkinson, R,
Paton, R,
Kawamura, A,
Mecinović, J |
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| 格式: | Journal article
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| 语言: | English |
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| 出版: |
Royal Society of Chemistry
2017
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