Decrease in breast cancer incidence following a rapid fall in use of hormone replacement therapy in Australia.
OBJECTIVE: To determine if the recent rapid fall in use of hormone replacement therapy (HRT) in Australia has been followed by a reduction in breast cancer incidence among women aged 50 years or older, but not among younger women. DESIGN AND SETTING: Analysis of trends in annual prescribing of HRT,...
| Главные авторы: | , , , |
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| Формат: | Journal article |
| Язык: | English |
| Опубликовано: |
2008
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| _version_ | 1826264941132251136 |
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| author | Canfell, K Banks, E Moa, A Beral, V |
| author_facet | Canfell, K Banks, E Moa, A Beral, V |
| author_sort | Canfell, K |
| collection | OXFORD |
| description | OBJECTIVE: To determine if the recent rapid fall in use of hormone replacement therapy (HRT) in Australia has been followed by a reduction in breast cancer incidence among women aged 50 years or older, but not among younger women. DESIGN AND SETTING: Analysis of trends in annual prescribing of HRT, using Pharmaceutical Benefits Scheme data, and in annual age-standardised breast cancer incidence rates in Australian women for the period 1996-2003. RESULTS: In Australia, prescribing of HRT increased from 1996 to 2001, but dropped by 40% from 2001 to 2003. Age-standardised breast cancer incidence rates in women aged > or = 50 years also increased to 2001 but declined thereafter. The incidence rates in this age group were lower by 6.7% (95% CI, 3.9%-9.3%; P < 0.001) in 2003 compared with 2001, equivalent to 600 (95% CI, 350-830) fewer breast cancers (out of about 9000 incident breast cancers annually for women this age). There was no significant change in breast cancer incidence for women aged < 50 years. CONCLUSIONS: While other factors may have contributed to a recent reduction in breast cancer incidence among Australian women aged > or = 50 years, the available evidence suggests that much of the decrease is due to the recent fall in use of HRT. This is consistent with other evidence that the HRT-associated increase in risk of breast cancer is reversible after ceasing use of HRT. |
| first_indexed | 2024-03-06T20:15:52Z |
| format | Journal article |
| id | oxford-uuid:2c1f816c-37cd-4e3b-a73f-f44e9b9a5f1b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:15:52Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:2c1f816c-37cd-4e3b-a73f-f44e9b9a5f1b2022-03-26T12:35:03ZDecrease in breast cancer incidence following a rapid fall in use of hormone replacement therapy in Australia.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2c1f816c-37cd-4e3b-a73f-f44e9b9a5f1bEnglishSymplectic Elements at Oxford2008Canfell, KBanks, EMoa, ABeral, V OBJECTIVE: To determine if the recent rapid fall in use of hormone replacement therapy (HRT) in Australia has been followed by a reduction in breast cancer incidence among women aged 50 years or older, but not among younger women. DESIGN AND SETTING: Analysis of trends in annual prescribing of HRT, using Pharmaceutical Benefits Scheme data, and in annual age-standardised breast cancer incidence rates in Australian women for the period 1996-2003. RESULTS: In Australia, prescribing of HRT increased from 1996 to 2001, but dropped by 40% from 2001 to 2003. Age-standardised breast cancer incidence rates in women aged > or = 50 years also increased to 2001 but declined thereafter. The incidence rates in this age group were lower by 6.7% (95% CI, 3.9%-9.3%; P < 0.001) in 2003 compared with 2001, equivalent to 600 (95% CI, 350-830) fewer breast cancers (out of about 9000 incident breast cancers annually for women this age). There was no significant change in breast cancer incidence for women aged < 50 years. CONCLUSIONS: While other factors may have contributed to a recent reduction in breast cancer incidence among Australian women aged > or = 50 years, the available evidence suggests that much of the decrease is due to the recent fall in use of HRT. This is consistent with other evidence that the HRT-associated increase in risk of breast cancer is reversible after ceasing use of HRT. |
| spellingShingle | Canfell, K Banks, E Moa, A Beral, V Decrease in breast cancer incidence following a rapid fall in use of hormone replacement therapy in Australia. |
| title | Decrease in breast cancer incidence following a rapid fall in use of hormone replacement therapy in Australia. |
| title_full | Decrease in breast cancer incidence following a rapid fall in use of hormone replacement therapy in Australia. |
| title_fullStr | Decrease in breast cancer incidence following a rapid fall in use of hormone replacement therapy in Australia. |
| title_full_unstemmed | Decrease in breast cancer incidence following a rapid fall in use of hormone replacement therapy in Australia. |
| title_short | Decrease in breast cancer incidence following a rapid fall in use of hormone replacement therapy in Australia. |
| title_sort | decrease in breast cancer incidence following a rapid fall in use of hormone replacement therapy in australia |
| work_keys_str_mv | AT canfellk decreaseinbreastcancerincidencefollowingarapidfallinuseofhormonereplacementtherapyinaustralia AT bankse decreaseinbreastcancerincidencefollowingarapidfallinuseofhormonereplacementtherapyinaustralia AT moaa decreaseinbreastcancerincidencefollowingarapidfallinuseofhormonereplacementtherapyinaustralia AT beralv decreaseinbreastcancerincidencefollowingarapidfallinuseofhormonereplacementtherapyinaustralia |