Novel Quinazolinone inhibitors of ALK2 flip between alternate binding modes: Structure-activity relationship, structural characterization, Kinase profiling, and cellular proof of concept
Structure-activity relationship and crystallographic data revealed that quinazolinone-containing fragments flip between two distinct modes of binding to activin receptor-like kinase-2 (ALK2). We explored both binding modes to discover potent inhibitors and characterized the chemical modifications th...
Full description
Bibliographic Details
| Main Authors: |
Hudson, L,
Mui, J,
Vázquez, S,
Carvalho, D,
Williams, E,
Jones, C,
Bullock, A,
Hoelder, S |
|---|
| Format: | Journal article
|
|---|
| Language: | English |
|---|
| Published: |
American Chemical Society
2018
|
|---|