Association of rheumatoid arthritis with an amino acid allelic variation of the T cell receptor.
OBJECTIVE: To investigate allelic variations of T cell receptor residues for a contribution to rheumatoid arthritis (RA) susceptibility. METHODS: We conducted an RA case-control study involving 1,579 northwest Europeans: 766 patients with erosive and rheumatoid factor-positive disease and 813 contro...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Conference item |
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1997
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| _version_ | 1797060355296329728 |
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| author | Cornélis, F Hardwick, L Flipo, R Martinez, M Lasbleiz, S Prud'homme, J Tran, T Walsh, S Delaye, A Nicod, A Loste, M Lepage, V Gibson, K Pile, K Djoulah, S Danzé, P Lioté, F Charron, D Weissenbach, J Kuntz, D Bardin, T Wordsworth, B |
| author_facet | Cornélis, F Hardwick, L Flipo, R Martinez, M Lasbleiz, S Prud'homme, J Tran, T Walsh, S Delaye, A Nicod, A Loste, M Lepage, V Gibson, K Pile, K Djoulah, S Danzé, P Lioté, F Charron, D Weissenbach, J Kuntz, D Bardin, T Wordsworth, B |
| author_sort | Cornélis, F |
| collection | OXFORD |
| description | OBJECTIVE: To investigate allelic variations of T cell receptor residues for a contribution to rheumatoid arthritis (RA) susceptibility. METHODS: We conducted an RA case-control study involving 1,579 northwest Europeans: 766 patients with erosive and rheumatoid factor-positive disease and 813 control subjects. Productive changes of segments TCRAV6S1, TCRAV7S1, TCRAV8S1, TCRAV10S2, and TCRBV6S1, TCRBV6S7 were investigated by single-strand conformation polymorphisms. The TCRAV8S1 association was confirmed by restriction fragment length polymorphism. RESULTS: In the systematic study (77 patients and 119 controls), an increase in 1 TCRAV8S1 genotype was found in the RA patients (P = 0.0004). This finding was replicated in 2 further populations, one from France (212 patients and 254 controls) and the other from Britain (477 patients and 440 controls), with a similar odds ratio (OR), which allowed pooling of the data and confirmation of the association (OR 1.3 [95% confidence interval 1.1-1.7], P = 0.008). CONCLUSION: These findings show evidence that TCRA is an RA susceptibility locus. |
| first_indexed | 2024-03-06T20:15:56Z |
| format | Conference item |
| id | oxford-uuid:2c25af78-bcc8-498a-bd08-73ded551f070 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T20:15:56Z |
| publishDate | 1997 |
| record_format | dspace |
| spelling | oxford-uuid:2c25af78-bcc8-498a-bd08-73ded551f0702022-03-26T12:35:16ZAssociation of rheumatoid arthritis with an amino acid allelic variation of the T cell receptor.Conference itemhttp://purl.org/coar/resource_type/c_5794uuid:2c25af78-bcc8-498a-bd08-73ded551f070Symplectic Elements at Oxford1997Cornélis, FHardwick, LFlipo, RMartinez, MLasbleiz, SPrud'homme, JTran, TWalsh, SDelaye, ANicod, ALoste, MLepage, VGibson, KPile, KDjoulah, SDanzé, PLioté, FCharron, DWeissenbach, JKuntz, DBardin, TWordsworth, BOBJECTIVE: To investigate allelic variations of T cell receptor residues for a contribution to rheumatoid arthritis (RA) susceptibility. METHODS: We conducted an RA case-control study involving 1,579 northwest Europeans: 766 patients with erosive and rheumatoid factor-positive disease and 813 control subjects. Productive changes of segments TCRAV6S1, TCRAV7S1, TCRAV8S1, TCRAV10S2, and TCRBV6S1, TCRBV6S7 were investigated by single-strand conformation polymorphisms. The TCRAV8S1 association was confirmed by restriction fragment length polymorphism. RESULTS: In the systematic study (77 patients and 119 controls), an increase in 1 TCRAV8S1 genotype was found in the RA patients (P = 0.0004). This finding was replicated in 2 further populations, one from France (212 patients and 254 controls) and the other from Britain (477 patients and 440 controls), with a similar odds ratio (OR), which allowed pooling of the data and confirmation of the association (OR 1.3 [95% confidence interval 1.1-1.7], P = 0.008). CONCLUSION: These findings show evidence that TCRA is an RA susceptibility locus. |
| spellingShingle | Cornélis, F Hardwick, L Flipo, R Martinez, M Lasbleiz, S Prud'homme, J Tran, T Walsh, S Delaye, A Nicod, A Loste, M Lepage, V Gibson, K Pile, K Djoulah, S Danzé, P Lioté, F Charron, D Weissenbach, J Kuntz, D Bardin, T Wordsworth, B Association of rheumatoid arthritis with an amino acid allelic variation of the T cell receptor. |
| title | Association of rheumatoid arthritis with an amino acid allelic variation of the T cell receptor. |
| title_full | Association of rheumatoid arthritis with an amino acid allelic variation of the T cell receptor. |
| title_fullStr | Association of rheumatoid arthritis with an amino acid allelic variation of the T cell receptor. |
| title_full_unstemmed | Association of rheumatoid arthritis with an amino acid allelic variation of the T cell receptor. |
| title_short | Association of rheumatoid arthritis with an amino acid allelic variation of the T cell receptor. |
| title_sort | association of rheumatoid arthritis with an amino acid allelic variation of the t cell receptor |
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