Complex haplotypic structure of the central MHC region flanking TNF in a West African population.
TNF polymorphisms have been associated with susceptibility to malaria and other infectious and inflammatory conditions. We investigated a sample of 150 West African chromosomes to determine linkage disequilibrium (LD) between 25 SNP markers located in an 80 kb segment of the MHC Class III region enc...
| Egile Nagusiak: | , , , , , , , , |
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| Formatua: | Journal article |
| Hizkuntza: | English |
| Argitaratua: |
2003
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| _version_ | 1826264954563461120 |
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| author | Ackerman, H Ribas, G Jallow, M Mott, R Neville, M Sisay-Joof, F Pinder, M Campbell, R Kwiatkowski, D |
| author_facet | Ackerman, H Ribas, G Jallow, M Mott, R Neville, M Sisay-Joof, F Pinder, M Campbell, R Kwiatkowski, D |
| author_sort | Ackerman, H |
| collection | OXFORD |
| description | TNF polymorphisms have been associated with susceptibility to malaria and other infectious and inflammatory conditions. We investigated a sample of 150 West African chromosomes to determine linkage disequilibrium (LD) between 25 SNP markers located in an 80 kb segment of the MHC Class III region encompassing TNF and eight neighbouring genes. We observed 45 haplotypes, and 22 of them comprise 80% of the sample. The pattern of LD is remarkably patchy, such that many markers show no LD with adjacent markers but high LD with markers that are much further away. We introduce a method of examining the implications of LD data for disease association studies based on sample size considerations: this shows that certain TNF polymorphisms would be likely to yield positive associations if the true disease allele resided in LTA or BAT1. We conclude that detailed marker maps are needed to resolve the causal origin of disease associations observed at the TNF locus. |
| first_indexed | 2024-03-06T20:16:05Z |
| format | Journal article |
| id | oxford-uuid:2c2d58e6-29f0-4c1f-8f15-a63d4d7e3e14 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:16:05Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:2c2d58e6-29f0-4c1f-8f15-a63d4d7e3e142022-03-26T12:35:28ZComplex haplotypic structure of the central MHC region flanking TNF in a West African population.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2c2d58e6-29f0-4c1f-8f15-a63d4d7e3e14EnglishSymplectic Elements at Oxford2003Ackerman, HRibas, GJallow, MMott, RNeville, MSisay-Joof, FPinder, MCampbell, RKwiatkowski, DTNF polymorphisms have been associated with susceptibility to malaria and other infectious and inflammatory conditions. We investigated a sample of 150 West African chromosomes to determine linkage disequilibrium (LD) between 25 SNP markers located in an 80 kb segment of the MHC Class III region encompassing TNF and eight neighbouring genes. We observed 45 haplotypes, and 22 of them comprise 80% of the sample. The pattern of LD is remarkably patchy, such that many markers show no LD with adjacent markers but high LD with markers that are much further away. We introduce a method of examining the implications of LD data for disease association studies based on sample size considerations: this shows that certain TNF polymorphisms would be likely to yield positive associations if the true disease allele resided in LTA or BAT1. We conclude that detailed marker maps are needed to resolve the causal origin of disease associations observed at the TNF locus. |
| spellingShingle | Ackerman, H Ribas, G Jallow, M Mott, R Neville, M Sisay-Joof, F Pinder, M Campbell, R Kwiatkowski, D Complex haplotypic structure of the central MHC region flanking TNF in a West African population. |
| title | Complex haplotypic structure of the central MHC region flanking TNF in a West African population. |
| title_full | Complex haplotypic structure of the central MHC region flanking TNF in a West African population. |
| title_fullStr | Complex haplotypic structure of the central MHC region flanking TNF in a West African population. |
| title_full_unstemmed | Complex haplotypic structure of the central MHC region flanking TNF in a West African population. |
| title_short | Complex haplotypic structure of the central MHC region flanking TNF in a West African population. |
| title_sort | complex haplotypic structure of the central mhc region flanking tnf in a west african population |
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