Innate immunology in COVID-19 – a living review. Part I: viral entry, sensing and evasion
The coronavirus infectious disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains a world health concern and can cause severe disease and high mortality in susceptible groups. While vaccines offer a chance to treat disease, prophylactic and an...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Oxford University Press
2020
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| _version_ | 1797060380632023040 |
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| author | Coveney, C Tellier, M Lu, F Toyserkani, SM Jones, R Bart, VMT Pring, E Alrubayyi, A Richter, FC Scourfield, DO Rehwinkel, J Rodrigues, PRS Davies, LC Gea-Mallorquí, E |
| author_facet | Coveney, C Tellier, M Lu, F Toyserkani, SM Jones, R Bart, VMT Pring, E Alrubayyi, A Richter, FC Scourfield, DO Rehwinkel, J Rodrigues, PRS Davies, LC Gea-Mallorquí, E |
| author_sort | Coveney, C |
| collection | OXFORD |
| description | The coronavirus infectious disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains a world health concern and can cause severe disease and high mortality in susceptible groups. While vaccines offer a chance to treat disease, prophylactic and anti-viral treatments are still of vital importance, especially in context of the mutative ability of this group of viruses. Therefore, it is essential to elucidate the molecular mechanisms of viral entry, innate sensing and immune evasion of SARS-CoV-2, which control the triggers of the subsequent excessive inflammatory response. Viral evasion strategies directly target anti-viral immunity, counteracting host restriction factors and hijacking signalling pathways to interfere with interferon production. In Part I of this review, we examine SARS-CoV-2 viral entry and the described immune evasion mechanisms to provide a perspective on how the failure in initial viral sensing by infected cells can lead to immune dysregulation causing fatal COVID-19, discussed in Part II. |
| first_indexed | 2024-03-06T20:16:19Z |
| format | Journal article |
| id | oxford-uuid:2c434156-50d9-493f-b2c3-c0ac2d076ff5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:16:19Z |
| publishDate | 2020 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:2c434156-50d9-493f-b2c3-c0ac2d076ff52022-03-26T12:35:58ZInnate immunology in COVID-19 – a living review. Part I: viral entry, sensing and evasionJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2c434156-50d9-493f-b2c3-c0ac2d076ff5EnglishSymplectic ElementsOxford University Press2020Coveney, CTellier, MLu, FToyserkani, SMJones, RBart, VMTPring, EAlrubayyi, ARichter, FCScourfield, DORehwinkel, JRodrigues, PRSDavies, LCGea-Mallorquí, EThe coronavirus infectious disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains a world health concern and can cause severe disease and high mortality in susceptible groups. While vaccines offer a chance to treat disease, prophylactic and anti-viral treatments are still of vital importance, especially in context of the mutative ability of this group of viruses. Therefore, it is essential to elucidate the molecular mechanisms of viral entry, innate sensing and immune evasion of SARS-CoV-2, which control the triggers of the subsequent excessive inflammatory response. Viral evasion strategies directly target anti-viral immunity, counteracting host restriction factors and hijacking signalling pathways to interfere with interferon production. In Part I of this review, we examine SARS-CoV-2 viral entry and the described immune evasion mechanisms to provide a perspective on how the failure in initial viral sensing by infected cells can lead to immune dysregulation causing fatal COVID-19, discussed in Part II. |
| spellingShingle | Coveney, C Tellier, M Lu, F Toyserkani, SM Jones, R Bart, VMT Pring, E Alrubayyi, A Richter, FC Scourfield, DO Rehwinkel, J Rodrigues, PRS Davies, LC Gea-Mallorquí, E Innate immunology in COVID-19 – a living review. Part I: viral entry, sensing and evasion |
| title | Innate immunology in COVID-19 – a living review. Part I: viral entry, sensing and evasion |
| title_full | Innate immunology in COVID-19 – a living review. Part I: viral entry, sensing and evasion |
| title_fullStr | Innate immunology in COVID-19 – a living review. Part I: viral entry, sensing and evasion |
| title_full_unstemmed | Innate immunology in COVID-19 – a living review. Part I: viral entry, sensing and evasion |
| title_short | Innate immunology in COVID-19 – a living review. Part I: viral entry, sensing and evasion |
| title_sort | innate immunology in covid 19 a living review part i viral entry sensing and evasion |
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