Discovering antisense reagents by hybridization of RNA to oligonucleotide arrays.

Antisense reagents have the potential to modify gene expression by interacting with DNA or mRNA to down-regulate transcription or translation. There have been a number of successful demonstrations of antisense activity in vivo. However, a number of problems must be solved before the method's fu...

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Autors principals: Southern, E, Milner, N, Mir, K
Format: Journal article
Idioma:English
Publicat: 1997