Host defences to Citrobacter rodentium.
Citrobacter rodentium is a natural non-invasive bacterial pathogen which infects the distal colon of mice. It uses the same molecular mechanisms of type III secretion as human enteropathogenic and enterohemorrhagic Escherichia coli to colonise the epithelial cells of the gut and is therefore an idea...
| Váldodahkkit: | , , , , |
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| Materiálatiipa: | Journal article |
| Giella: | English |
| Almmustuhtton: |
2003
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| _version_ | 1826264998163251200 |
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| author | MacDonald, T Frankel, G Dougan, G Goncalves, N Simmons, C |
| author_facet | MacDonald, T Frankel, G Dougan, G Goncalves, N Simmons, C |
| author_sort | MacDonald, T |
| collection | OXFORD |
| description | Citrobacter rodentium is a natural non-invasive bacterial pathogen which infects the distal colon of mice. It uses the same molecular mechanisms of type III secretion as human enteropathogenic and enterohemorrhagic Escherichia coli to colonise the epithelial cells of the gut and is therefore an ideal model to study host-bacterial pathogen interactions in vivo. Infection elicits mucosal inflammation with similarities to inflammatory bowel disease, and so it is a readily accessible model to investigate the relationship between inflammation and anti-bacterial immunity in the gut. |
| first_indexed | 2024-03-06T20:16:45Z |
| format | Journal article |
| id | oxford-uuid:2c62d80c-0dde-4a14-9817-c34d1d8bba59 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:16:45Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:2c62d80c-0dde-4a14-9817-c34d1d8bba592022-03-26T12:36:50ZHost defences to Citrobacter rodentium.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2c62d80c-0dde-4a14-9817-c34d1d8bba59EnglishSymplectic Elements at Oxford2003MacDonald, TFrankel, GDougan, GGoncalves, NSimmons, CCitrobacter rodentium is a natural non-invasive bacterial pathogen which infects the distal colon of mice. It uses the same molecular mechanisms of type III secretion as human enteropathogenic and enterohemorrhagic Escherichia coli to colonise the epithelial cells of the gut and is therefore an ideal model to study host-bacterial pathogen interactions in vivo. Infection elicits mucosal inflammation with similarities to inflammatory bowel disease, and so it is a readily accessible model to investigate the relationship between inflammation and anti-bacterial immunity in the gut. |
| spellingShingle | MacDonald, T Frankel, G Dougan, G Goncalves, N Simmons, C Host defences to Citrobacter rodentium. |
| title | Host defences to Citrobacter rodentium. |
| title_full | Host defences to Citrobacter rodentium. |
| title_fullStr | Host defences to Citrobacter rodentium. |
| title_full_unstemmed | Host defences to Citrobacter rodentium. |
| title_short | Host defences to Citrobacter rodentium. |
| title_sort | host defences to citrobacter rodentium |
| work_keys_str_mv | AT macdonaldt hostdefencestocitrobacterrodentium AT frankelg hostdefencestocitrobacterrodentium AT dougang hostdefencestocitrobacterrodentium AT goncalvesn hostdefencestocitrobacterrodentium AT simmonsc hostdefencestocitrobacterrodentium |