Microevolution of Burkholderia pseudomallei during an acute infection.

We used whole-genome sequencing to evaluate 69 independent colonies of Burkholderia pseudomallei isolated from seven body sites of a patient with acute disseminated melioidosis. Fourteen closely related genotypes were found, providing evidence for the rapid in vivo diversification of B. pseudomallei...

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Xehetasun bibliografikoak
Egile Nagusiak: Limmathurotsakul, D, Holden, M, Coupland, P, Price, E, Chantratita, N, Wuthiekanun, V, Amornchai, P, Parkhill, J, Peacock, S
Formatua: Journal article
Hizkuntza:English
Argitaratua: American Society for Microbiology 2014
Deskribapena
Gaia:We used whole-genome sequencing to evaluate 69 independent colonies of Burkholderia pseudomallei isolated from seven body sites of a patient with acute disseminated melioidosis. Fourteen closely related genotypes were found, providing evidence for the rapid in vivo diversification of B. pseudomallei after inoculation and systemic spread.