The relationship between visual acuity loss and GABAergic inhibition in amblyopia
Early childhood experience alters visual development, a process exemplified by amblyopia, a common neurodevelopmental condition resulting in cortically reduced vision in one eye. Visual deficits in amblyopia may be a consequence of abnormal suppressive interactions in the primary visual cortex by in...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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MIT Press
2024
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| _version_ | 1811140218490716160 |
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| author | Ip, IB Clarke, WT Wyllie, A Tracey, K Matuszewski, J Jbabdi, S Starling, L Templer, S Willis, H Breach, L Parker, AJ Bridge, H |
| author_facet | Ip, IB Clarke, WT Wyllie, A Tracey, K Matuszewski, J Jbabdi, S Starling, L Templer, S Willis, H Breach, L Parker, AJ Bridge, H |
| author_sort | Ip, IB |
| collection | OXFORD |
| description | Early childhood experience alters visual development, a process exemplified by amblyopia, a common neurodevelopmental condition resulting in cortically reduced vision in one eye. Visual deficits in amblyopia may be a consequence of abnormal suppressive interactions in the primary visual cortex by inhibitory neurotransmitter γ-aminobutyric acid (GABA). We examined the relationship between visual acuity loss and GABA+ in adult human participants with amblyopia. Single voxel proton magnetic resonance spectroscopy (MRS) data were collected from the early visual cortex (EVC) and posterior cingulate cortex (control region) of twenty-eight male and female adults with current or past amblyopia while they viewed flashing checkerboards monocularly, binocularly, or while they had their eyes closed. First, we compared GABA+ concentrations between conditions to evaluate suppressive binocular interactions. Then, we correlated the degree of visual acuity loss with GABA+ levels to test whether GABAergic inhibition could explain visual acuity deficits. Visual cortex GABA+ was not modulated by viewing condition, and we found weak evidence for a negative correlation between visual acuity deficits and GABA+. These findings suggest that reduced vision in one eye due to amblyopia is not strongly linked to GABAergic inhibition in the visual cortex. We advanced our understanding of early experience dependent plasticity in the human brain by testing the association between visual acuity deficits and visual cortex GABA in amblyopes of the most common subtypes. Our study shows that the relationship was not as clear as expected and provides avenues for future investigation. |
| first_indexed | 2024-09-25T04:18:29Z |
| format | Journal article |
| id | oxford-uuid:2ccce170-d86c-4b1c-851a-6e87deb5b281 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:18:29Z |
| publishDate | 2024 |
| publisher | MIT Press |
| record_format | dspace |
| spelling | oxford-uuid:2ccce170-d86c-4b1c-851a-6e87deb5b2812024-07-31T12:22:00ZThe relationship between visual acuity loss and GABAergic inhibition in amblyopiaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2ccce170-d86c-4b1c-851a-6e87deb5b281EnglishSymplectic ElementsMIT Press2024Ip, IBClarke, WTWyllie, ATracey, KMatuszewski, JJbabdi, SStarling, LTempler, SWillis, HBreach, LParker, AJBridge, HEarly childhood experience alters visual development, a process exemplified by amblyopia, a common neurodevelopmental condition resulting in cortically reduced vision in one eye. Visual deficits in amblyopia may be a consequence of abnormal suppressive interactions in the primary visual cortex by inhibitory neurotransmitter γ-aminobutyric acid (GABA). We examined the relationship between visual acuity loss and GABA+ in adult human participants with amblyopia. Single voxel proton magnetic resonance spectroscopy (MRS) data were collected from the early visual cortex (EVC) and posterior cingulate cortex (control region) of twenty-eight male and female adults with current or past amblyopia while they viewed flashing checkerboards monocularly, binocularly, or while they had their eyes closed. First, we compared GABA+ concentrations between conditions to evaluate suppressive binocular interactions. Then, we correlated the degree of visual acuity loss with GABA+ levels to test whether GABAergic inhibition could explain visual acuity deficits. Visual cortex GABA+ was not modulated by viewing condition, and we found weak evidence for a negative correlation between visual acuity deficits and GABA+. These findings suggest that reduced vision in one eye due to amblyopia is not strongly linked to GABAergic inhibition in the visual cortex. We advanced our understanding of early experience dependent plasticity in the human brain by testing the association between visual acuity deficits and visual cortex GABA in amblyopes of the most common subtypes. Our study shows that the relationship was not as clear as expected and provides avenues for future investigation. |
| spellingShingle | Ip, IB Clarke, WT Wyllie, A Tracey, K Matuszewski, J Jbabdi, S Starling, L Templer, S Willis, H Breach, L Parker, AJ Bridge, H The relationship between visual acuity loss and GABAergic inhibition in amblyopia |
| title | The relationship between visual acuity loss and GABAergic inhibition in amblyopia |
| title_full | The relationship between visual acuity loss and GABAergic inhibition in amblyopia |
| title_fullStr | The relationship between visual acuity loss and GABAergic inhibition in amblyopia |
| title_full_unstemmed | The relationship between visual acuity loss and GABAergic inhibition in amblyopia |
| title_short | The relationship between visual acuity loss and GABAergic inhibition in amblyopia |
| title_sort | relationship between visual acuity loss and gabaergic inhibition in amblyopia |
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