Recent advances in the understanding of Dupuytren's disease
Dupuytren’s disease (DD) is a common fibrotic disorder of the hand and can significantly impair hand function. Although the exact pathogenesis of this disorder remains to be elucidated, immunological, genetic and cellular factors likely interact. In this review, we summarise recent advances in the u...
| Main Authors: | , |
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| Format: | Journal article |
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F1000Research
2019
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| _version_ | 1797060552557592576 |
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| author | Nanchahal, J Layton, T |
| author_facet | Nanchahal, J Layton, T |
| author_sort | Nanchahal, J |
| collection | OXFORD |
| description | Dupuytren’s disease (DD) is a common fibrotic disorder of the hand and can significantly impair hand function. Although the exact pathogenesis of this disorder remains to be elucidated, immunological, genetic and cellular factors likely interact. In this review, we summarise recent advances in the understanding of DD pathogenesis and look to the future for potential novel therapeutic targets. In addition, we discuss the therapeutic options in DD with a focus on the need for more rigorous evidence to allow a meaningful comparison of different treatment modalities. |
| first_indexed | 2024-03-06T20:18:41Z |
| format | Journal article |
| id | oxford-uuid:2d0cbd47-2458-4330-abf3-7740ad8043a0 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T20:18:41Z |
| publishDate | 2019 |
| publisher | F1000Research |
| record_format | dspace |
| spelling | oxford-uuid:2d0cbd47-2458-4330-abf3-7740ad8043a02022-03-26T12:40:32ZRecent advances in the understanding of Dupuytren's diseaseJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2d0cbd47-2458-4330-abf3-7740ad8043a0Symplectic Elements at OxfordF1000Research2019Nanchahal, JLayton, TDupuytren’s disease (DD) is a common fibrotic disorder of the hand and can significantly impair hand function. Although the exact pathogenesis of this disorder remains to be elucidated, immunological, genetic and cellular factors likely interact. In this review, we summarise recent advances in the understanding of DD pathogenesis and look to the future for potential novel therapeutic targets. In addition, we discuss the therapeutic options in DD with a focus on the need for more rigorous evidence to allow a meaningful comparison of different treatment modalities. |
| spellingShingle | Nanchahal, J Layton, T Recent advances in the understanding of Dupuytren's disease |
| title | Recent advances in the understanding of Dupuytren's disease |
| title_full | Recent advances in the understanding of Dupuytren's disease |
| title_fullStr | Recent advances in the understanding of Dupuytren's disease |
| title_full_unstemmed | Recent advances in the understanding of Dupuytren's disease |
| title_short | Recent advances in the understanding of Dupuytren's disease |
| title_sort | recent advances in the understanding of dupuytren s disease |
| work_keys_str_mv | AT nanchahalj recentadvancesintheunderstandingofdupuytrensdisease AT laytont recentadvancesintheunderstandingofdupuytrensdisease |