A network aggregation model for amyloid-β dynamics and treatment of Alzheimer’s diseases at the brain scale
Neurodegenerative diseases are associated with the assembly of specific proteins into oligomers and fibrillar aggregates. At the brain scale, these protein assemblies can diffuse through the brain and seed other regions, creating an autocatalytic protein progression. The growth and transport of thes...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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Springer
2025
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| _version_ | 1824459069582213120 |
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| author | Brennan, GS Goriely, A |
| author_facet | Brennan, GS Goriely, A |
| author_sort | Brennan, GS |
| collection | OXFORD |
| description | Neurodegenerative diseases are associated with the assembly of specific proteins into oligomers and fibrillar aggregates. At the brain scale, these protein assemblies can diffuse through the brain and seed other regions, creating an autocatalytic protein progression. The growth and transport of these assemblies depend on various mechanisms that can be targeted therapeutically. Here, we use spatially-extended nucleation-aggregation-fragmentation models for the dynamics of prion-like neurodegenerative protein-spreading in the brain to study the effect of different drugs on whole-brain Alzheimer’s disease progression. |
| first_indexed | 2025-02-19T04:35:55Z |
| format | Journal article |
| id | oxford-uuid:2d2b0bed-1032-40e4-859c-9915a0d19a34 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2025-02-19T04:35:55Z |
| publishDate | 2025 |
| publisher | Springer |
| record_format | dspace |
| spelling | oxford-uuid:2d2b0bed-1032-40e4-859c-9915a0d19a342025-02-03T09:03:49ZA network aggregation model for amyloid-β dynamics and treatment of Alzheimer’s diseases at the brain scaleJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2d2b0bed-1032-40e4-859c-9915a0d19a34EnglishSymplectic ElementsSpringer2025Brennan, GSGoriely, ANeurodegenerative diseases are associated with the assembly of specific proteins into oligomers and fibrillar aggregates. At the brain scale, these protein assemblies can diffuse through the brain and seed other regions, creating an autocatalytic protein progression. The growth and transport of these assemblies depend on various mechanisms that can be targeted therapeutically. Here, we use spatially-extended nucleation-aggregation-fragmentation models for the dynamics of prion-like neurodegenerative protein-spreading in the brain to study the effect of different drugs on whole-brain Alzheimer’s disease progression. |
| spellingShingle | Brennan, GS Goriely, A A network aggregation model for amyloid-β dynamics and treatment of Alzheimer’s diseases at the brain scale |
| title | A network aggregation model for amyloid-β dynamics and treatment of Alzheimer’s diseases at the brain scale |
| title_full | A network aggregation model for amyloid-β dynamics and treatment of Alzheimer’s diseases at the brain scale |
| title_fullStr | A network aggregation model for amyloid-β dynamics and treatment of Alzheimer’s diseases at the brain scale |
| title_full_unstemmed | A network aggregation model for amyloid-β dynamics and treatment of Alzheimer’s diseases at the brain scale |
| title_short | A network aggregation model for amyloid-β dynamics and treatment of Alzheimer’s diseases at the brain scale |
| title_sort | network aggregation model for amyloid β dynamics and treatment of alzheimer s diseases at the brain scale |
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