Tough photo-cross-linked PCL-hydroxyapatite composites for bone tissue engineering
Acrylate-based photo-cross-linked poly(ε-caprolactone) (PCL) tends to show low elongation and strength. Incorporation of osteo-inductive hydroxyapatite (HAp) further enhances this effect, which limits its applicability in bone tissue engineering. To overcome this, the thiol-ene click react...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
American Chemical Society
2022
|
| _version_ | 1826307307050369024 |
|---|---|
| author | Thijssen, Q Cornelis, K Alkaissy, R Locs, J Damme, LV Schaubroeck, D Willaert, R Snelling, S Mouthuy, P-A Van Vlierberghe, S |
| author_facet | Thijssen, Q Cornelis, K Alkaissy, R Locs, J Damme, LV Schaubroeck, D Willaert, R Snelling, S Mouthuy, P-A Van Vlierberghe, S |
| author_sort | Thijssen, Q |
| collection | OXFORD |
| description | Acrylate-based photo-cross-linked poly(ε-caprolactone) (PCL) tends to show low elongation and strength. Incorporation of osteo-inductive hydroxyapatite (HAp) further enhances this effect, which limits its applicability in bone tissue engineering. To overcome this, the thiol-ene click reaction is introduced for the first time in order to photo-cross-link PCL composites with 0, 10, 20, and 30 wt % HAp nanoparticles. It is demonstrated that the elongation at break and ultimate strength increase 10- and 2-fold, respectively, when the photopolymerization mechanism is shifted from a radical chain-growth (i.e., acrylate cross-linking) toward a radical step-growth polymerization (i.e., thiol-ene cross-linking). Additionally, it is illustrated that osteoblasts can attach to and proliferate on the surface of the photo-cross-linked PCL-HAp composites. Finally, the incorporation of HAp nanoparticles is shown to reduce the ALP activity of osteoblasts. Overall, thiol-ene cross-linked PCL-HAp composites can be considered as promising potential materials for bone tissue engineering. |
| first_indexed | 2024-03-07T07:01:11Z |
| format | Journal article |
| id | oxford-uuid:2d2e2aab-7ee7-43d7-a3cf-af3967fcccc8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:01:11Z |
| publishDate | 2022 |
| publisher | American Chemical Society |
| record_format | dspace |
| spelling | oxford-uuid:2d2e2aab-7ee7-43d7-a3cf-af3967fcccc82022-03-28T11:17:21ZTough photo-cross-linked PCL-hydroxyapatite composites for bone tissue engineeringJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2d2e2aab-7ee7-43d7-a3cf-af3967fcccc8EnglishEnglishAmerican Chemical Society2022Thijssen, QCornelis, KAlkaissy, RLocs, JDamme, LVSchaubroeck, DWillaert, RSnelling, SMouthuy, P-AVan Vlierberghe, SAcrylate-based photo-cross-linked poly(ε-caprolactone) (PCL) tends to show low elongation and strength. Incorporation of osteo-inductive hydroxyapatite (HAp) further enhances this effect, which limits its applicability in bone tissue engineering. To overcome this, the thiol-ene click reaction is introduced for the first time in order to photo-cross-link PCL composites with 0, 10, 20, and 30 wt % HAp nanoparticles. It is demonstrated that the elongation at break and ultimate strength increase 10- and 2-fold, respectively, when the photopolymerization mechanism is shifted from a radical chain-growth (i.e., acrylate cross-linking) toward a radical step-growth polymerization (i.e., thiol-ene cross-linking). Additionally, it is illustrated that osteoblasts can attach to and proliferate on the surface of the photo-cross-linked PCL-HAp composites. Finally, the incorporation of HAp nanoparticles is shown to reduce the ALP activity of osteoblasts. Overall, thiol-ene cross-linked PCL-HAp composites can be considered as promising potential materials for bone tissue engineering. |
| spellingShingle | Thijssen, Q Cornelis, K Alkaissy, R Locs, J Damme, LV Schaubroeck, D Willaert, R Snelling, S Mouthuy, P-A Van Vlierberghe, S Tough photo-cross-linked PCL-hydroxyapatite composites for bone tissue engineering |
| title | Tough photo-cross-linked PCL-hydroxyapatite composites for bone tissue engineering |
| title_full | Tough photo-cross-linked PCL-hydroxyapatite composites for bone tissue engineering |
| title_fullStr | Tough photo-cross-linked PCL-hydroxyapatite composites for bone tissue engineering |
| title_full_unstemmed | Tough photo-cross-linked PCL-hydroxyapatite composites for bone tissue engineering |
| title_short | Tough photo-cross-linked PCL-hydroxyapatite composites for bone tissue engineering |
| title_sort | tough photo cross linked pcl hydroxyapatite composites for bone tissue engineering |
| work_keys_str_mv | AT thijssenq toughphotocrosslinkedpclhydroxyapatitecompositesforbonetissueengineering AT cornelisk toughphotocrosslinkedpclhydroxyapatitecompositesforbonetissueengineering AT alkaissyr toughphotocrosslinkedpclhydroxyapatitecompositesforbonetissueengineering AT locsj toughphotocrosslinkedpclhydroxyapatitecompositesforbonetissueengineering AT dammelv toughphotocrosslinkedpclhydroxyapatitecompositesforbonetissueengineering AT schaubroeckd toughphotocrosslinkedpclhydroxyapatitecompositesforbonetissueengineering AT willaertr toughphotocrosslinkedpclhydroxyapatitecompositesforbonetissueengineering AT snellings toughphotocrosslinkedpclhydroxyapatitecompositesforbonetissueengineering AT mouthuypa toughphotocrosslinkedpclhydroxyapatitecompositesforbonetissueengineering AT vanvlierberghes toughphotocrosslinkedpclhydroxyapatitecompositesforbonetissueengineering |