POLE proofreading mutation, immune response and prognosis in endometrial cancer
<p style="text-align:justify;"> Endometrial cancers (ECs) with POLE proofreading mutations are typified by ultramutation and excellent prognosis. We investigated whether these were related, and found that POLE-mutant ECs display a robust T cell response that corresponds to an enrich...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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Taylor and Francis
2015
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| _version_ | 1797060578255044608 |
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| author | Van Gool, I Bosse, T Church, D |
| author_facet | Van Gool, I Bosse, T Church, D |
| author_sort | Van Gool, I |
| collection | OXFORD |
| description | <p style="text-align:justify;"> Endometrial cancers (ECs) with POLE proofreading mutations are typified by ultramutation and excellent prognosis. We investigated whether these were related, and found that POLE-mutant ECs display a robust T cell response that corresponds to an enrichment of antigenic tumor neopeptides. Enhanced immunogenicity may explain the favorable outcome of POLE-mutant ECs. </p> |
| first_indexed | 2024-03-06T20:19:03Z |
| format | Journal article |
| id | oxford-uuid:2d2e2f14-53a6-4b15-8106-c1198bcb3f8a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:19:03Z |
| publishDate | 2015 |
| publisher | Taylor and Francis |
| record_format | dspace |
| spelling | oxford-uuid:2d2e2f14-53a6-4b15-8106-c1198bcb3f8a2022-03-26T12:41:13ZPOLE proofreading mutation, immune response and prognosis in endometrial cancerJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2d2e2f14-53a6-4b15-8106-c1198bcb3f8aEnglishSymplectic Elements at OxfordTaylor and Francis2015Van Gool, IBosse, TChurch, D <p style="text-align:justify;"> Endometrial cancers (ECs) with POLE proofreading mutations are typified by ultramutation and excellent prognosis. We investigated whether these were related, and found that POLE-mutant ECs display a robust T cell response that corresponds to an enrichment of antigenic tumor neopeptides. Enhanced immunogenicity may explain the favorable outcome of POLE-mutant ECs. </p> |
| spellingShingle | Van Gool, I Bosse, T Church, D POLE proofreading mutation, immune response and prognosis in endometrial cancer |
| title | POLE proofreading mutation, immune response and prognosis in endometrial cancer |
| title_full | POLE proofreading mutation, immune response and prognosis in endometrial cancer |
| title_fullStr | POLE proofreading mutation, immune response and prognosis in endometrial cancer |
| title_full_unstemmed | POLE proofreading mutation, immune response and prognosis in endometrial cancer |
| title_short | POLE proofreading mutation, immune response and prognosis in endometrial cancer |
| title_sort | pole proofreading mutation immune response and prognosis in endometrial cancer |
| work_keys_str_mv | AT vangooli poleproofreadingmutationimmuneresponseandprognosisinendometrialcancer AT bosset poleproofreadingmutationimmuneresponseandprognosisinendometrialcancer AT churchd poleproofreadingmutationimmuneresponseandprognosisinendometrialcancer |