NAADP receptors.
Of the established Ca(2+) mobilizing messengers, NAADP is arguably the most tantalizing. It is the most potent, often efficacious at low nanomolar concentrations. Recent studies have identified a new class of calcium release channel, the two-pore channels (TPCs), as the likely targets for NAADP. The...
| Main Author: | |
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| Format: | Journal article |
| Language: | English |
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2011
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| _version_ | 1797060622630780928 |
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| author | Galione, A |
| author_facet | Galione, A |
| author_sort | Galione, A |
| collection | OXFORD |
| description | Of the established Ca(2+) mobilizing messengers, NAADP is arguably the most tantalizing. It is the most potent, often efficacious at low nanomolar concentrations. Recent studies have identified a new class of calcium release channel, the two-pore channels (TPCs), as the likely targets for NAADP. These channels are endolysosomal in localization where they mediate local Ca(2+) release, and have highlighted a new role of acidic organelles as targets for messenger-evoked Ca(2+) mobilization. Three distinct roles of TPCs have been identified. The first is to effect local Ca(2+) release that may play a role in endolysosomal function including vesicular fusion and trafficking. The second is to trigger global calcium release by recruiting Ca(2+)-induced Ca(2+) release (CICR) channels at lysosomal-ER junctions. The third is to regulate plasma membrane excitability by the targeting of Ca(2+) release from appropriately positioned subplasma membrane stores to regulate plasma membrane Ca(2+)-activated channels. In this review, I discuss the role of NAADP-mediated Ca(2+) release from endolysosomal stores as a widespread trigger for intracellular calcium signaling mechanisms, and how studies of TPCs are beginning to enhance our understanding of the central role of lysosomes in Ca(2+) signaling. |
| first_indexed | 2024-03-06T20:19:41Z |
| format | Journal article |
| id | oxford-uuid:2d5d53dc-7581-4f6e-8d71-bcf684fa5d2c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:19:41Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:2d5d53dc-7581-4f6e-8d71-bcf684fa5d2c2022-03-26T12:42:32ZNAADP receptors.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2d5d53dc-7581-4f6e-8d71-bcf684fa5d2cEnglishSymplectic Elements at Oxford2011Galione, AOf the established Ca(2+) mobilizing messengers, NAADP is arguably the most tantalizing. It is the most potent, often efficacious at low nanomolar concentrations. Recent studies have identified a new class of calcium release channel, the two-pore channels (TPCs), as the likely targets for NAADP. These channels are endolysosomal in localization where they mediate local Ca(2+) release, and have highlighted a new role of acidic organelles as targets for messenger-evoked Ca(2+) mobilization. Three distinct roles of TPCs have been identified. The first is to effect local Ca(2+) release that may play a role in endolysosomal function including vesicular fusion and trafficking. The second is to trigger global calcium release by recruiting Ca(2+)-induced Ca(2+) release (CICR) channels at lysosomal-ER junctions. The third is to regulate plasma membrane excitability by the targeting of Ca(2+) release from appropriately positioned subplasma membrane stores to regulate plasma membrane Ca(2+)-activated channels. In this review, I discuss the role of NAADP-mediated Ca(2+) release from endolysosomal stores as a widespread trigger for intracellular calcium signaling mechanisms, and how studies of TPCs are beginning to enhance our understanding of the central role of lysosomes in Ca(2+) signaling. |
| spellingShingle | Galione, A NAADP receptors. |
| title | NAADP receptors. |
| title_full | NAADP receptors. |
| title_fullStr | NAADP receptors. |
| title_full_unstemmed | NAADP receptors. |
| title_short | NAADP receptors. |
| title_sort | naadp receptors |
| work_keys_str_mv | AT galionea naadpreceptors |