Overexpressing centriole-replication proteins in vivo induces centriole overduplication and de novo formation.

Overexpressing centriole-replication proteins in vivo induces centriole overduplication and de novo formation.

BACKGROUND: Centrosomes have important roles in many aspects of cell organization, and aberrations in their number and function are associated with various diseases, including cancer. Centrosomes consist of a pair of centrioles surrounded by a pericentriolar matrix (PCM), and their replication is t...

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Autors principals:	Peel, N, Stevens, N, Basto, R, Raff, J
Format:	Journal article
Idioma:	English
Publicat:	2007

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