Overexpressing centriole-replication proteins in vivo induces centriole overduplication and de novo formation.
BACKGROUND: Centrosomes have important roles in many aspects of cell organization, and aberrations in their number and function are associated with various diseases, including cancer. Centrosomes consist of a pair of centrioles surrounded by a pericentriolar matrix (PCM), and their replication is t...
Asıl Yazarlar: | Peel, N, Stevens, N, Basto, R, Raff, J |
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Materyal Türü: | Journal article |
Dil: | English |
Baskı/Yayın Bilgisi: |
2007
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