The HCM-associated cardiac Troponin T mutation K280N causes reduced responsiveness to protein kinase A

The HCM-associated cardiac Troponin T mutation K280N causes reduced responsiveness to protein kinase A

Detalhes bibliográficos
Principais autores:	Van Der Velden, J, Kooij, V, Sequiera, V, Stienen, G, Dooijes, D, Carrier, L, Marston, S, Redwood, C, Dos Remedios, C, Poggesi, C
Formato:	Conference item
Publicado em:	2012

Registros relacionados

The HCM-Associated Cardiac Troponin T Mutation K280N Increases the Energetic Cost of Tension Generation in Human Cardiac Myofibrils
por: Ferrara, C, et al.
Publicado em: (2013)

Functional investigation of troponin with the homozygous HCM mutation, TNNT2 K280N, obtained from an explanted heart
por: Bayliss, C, et al.
Publicado em: (2012)

The effect of HCM mutations in troponin T and troponin I on the calcium binding of human cardiac troponin
por: Redwood, C, et al.
Publicado em: (2001)

In vitro motility studies of HCM and DCM mutations in cardiac muscle actin
por: Dyer, E, et al.
Publicado em: (2007)

A revised method of troponin exchange in permeabilised cardiac trabeculae using vanadate: functional consequences of a HCM-causing mutation in troponin I.
por: Preston, L, et al.
Publicado em: (2006)

HCM and DCM mutations in cardiac thin filament proteins have opposite effects on the regulation of contractility in vitro
por: Redwood, C, et al.
Publicado em: (2003)

Evidence for haploinsufficiency as the mechanism of action of MyBP-C mutations that cause HCM
por: Carballo, S, et al.
Publicado em: (2008)

HCM and DCM mutations in thin filament proteins have opposite effects on in vitro motility
por: Marston, S, et al.
Publicado em: (2002)

HCM and DCM mutations in thin filament proteins have opposite effects on regulation of contractility in vitro
por: Redwood, C, et al.
Publicado em: (2003)

Interaction analyses elucidate the pathophysiology of HCM-causing missense mutations in cardiac myosin binding protein-C.
por: Moolman-Smook, J, et al.
Publicado em: (2001)

Mouse HCM Model Expression E99K ACTC Mutation Reproduces the Clinical HCM Phenotype
por: Song, W, et al.
Publicado em: (2009)

Mutations in troponin T associated with Hypertrophic Cardiomyopathy increase Ca2+-sensitivity and suppress the modulation of Ca2+-sensitivity by troponin I phosphorylation
por: Messer, A, et al.
Publicado em: (2016)

Two mutations in troponin I that cause hypertrophic cardiomyopathy have contrasting effects on cardiac muscle contractility.
por: Burton, D, et al.
Publicado em: (2002)

Dilated cardiomyopathy causing mutations in cardiac troponin T (TNT), cardiac troponin C (TNC), and alpha tropomyosin (TM) reduce CA(2+) sensitivity and maximum calcium activation
por: Redwood, C, et al.
Publicado em: (2004)

Investigation of troponin I mutations causing familial hypertrophic cardiomyopathy
por: Abdulrazzak, H, et al.
Publicado em: (2001)

Functional effects of mutations in troponin T and tropomyosin which cause dilated cardiomyopathy
por: Robinson, P, et al.
Publicado em: (2003)

Cardiac troponin I is a potential novel substrate for AMP-activated protein kinase
por: Oliveira, S, et al.
Publicado em: (2007)

Effects of hypertrophic cardiomyopathy mutations in troponin I on contractility of skinned cardiac muscle fibres
por: Burton, D, et al.
Publicado em: (2002)

Investigating the Effect of Cardiomyopathy-Causing Mutations in Cardiac Troponin-T on Calcium Buffering In Situ
por: Robinson, P, et al.
Publicado em: (2010)

Low expression of the K280N TNNT2 mutation is sufficient to increase basal myofilament activation in human hypertrophy cardiomyopathy
por: Vasco Sequeira, et al.
Publicado em: (2022-09-01)

Comparison of the functional effects of mutations in troponin T which cause dilated and hypertrophic cardiomyopathies
por: Robinson, P, et al.
Publicado em: (2002)

Effect of hypertrophic cardiomyopathy mutations in human cardiac muscle alpha -tropomyosin (Asp175Asn and Glu180Gly) on the regulatory properties of human cardiac troponin determined by in vitro motility assay.
por: Bing, W, et al.
Publicado em: (2000)

Two mutations in human cardiac troponin I known to cause hypertrophic cardiomyopathy have different effects on cardiac muscle contraction
por: Burton, D, et al.
Publicado em: (2000)

Altered inhibitory and troponin C-binding activities in cardiac troponin I mutants known to cause hypertrophic cardiomyopathy
por: Elliott, K, et al.
Publicado em: (2000)

Myofibrillar Ca(2+) sensitivity is uncoupled from troponin I phosphorylation in hypertrophic obstructive cardiomyopathy due to abnormal troponin T.
por: Bayliss, C, et al.
Publicado em: (2013)

Structure-function relationships of eight mutations in troponin and tropomyosin that cause dilated cardiomyopathy
por: Mirza, M, et al.
Publicado em: (2004)

Nutraceuticals silybin B, resveratrol, and epigallocatechin-3 gallate-bind to cardiac muscle troponin to restore the loss of lusitropy caused by cardiomyopathy mutations in vitro, in vivo, and in silico
por: Yang, Z, et al.
Publicado em: (2024)

Mutations in fast skeletal troponin I, troponin T and beta-tropomyosin that cause distal arthrogryposis all enhance thin filament activation
por: Robinson, P, et al.
Publicado em: (2005)

Alterations in thin filament regulation induced by a human cardiac troponin T mutant that causes dilated cardiomyopathy are distinct from those induced by troponin T mutants that cause hypertrophic cardiomyopathy.
por: Robinson, P, et al.
Publicado em: (2002)

Delineating the role of adenosine monophosphate (AMP)-activated protein kinase (AMP) gamma 2 subunit in hypertrophic cardiomyopathy (HCM)
por: Grignani, R, et al.
Publicado em: (2005)

Dilated and hypertrophic cardiomyopathy mutations in troponin and alpha-tropomyosin have opposing effects on the calcium affinity of cardiac thin filaments.
por: Robinson, P, et al.
Publicado em: (2007)

Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy.
por: Mogensen, J, et al.
Publicado em: (2004)

A novel interaction between the C5 and C8 domains of myosin binding protein-C and its modulation by HCM mutations
por: Flashman, E, et al.
Publicado em: (2002)

Mechanical effects of human cardiac troponin C mutation Gly159Asp in exchanged rabbit psoas fibres
por: Preston, L, et al.
Publicado em: (2004)

Effects of the mutation R145G in human cardiac troponin I on the kinetics of the contraction-relaxation cycle in isolated cardiac myofibrils.
por: Kruger, M, et al.
Publicado em: (2005)

Using fluorescence emission spectroscopy to asses the Ca2+ affinity of reconstituted troponin and thin filaments containing cardiomyopathy causing mutations of troponin and alpha-tropomyosin
por: Robinson, P, et al.
Publicado em: (2007)

Mutations in fast skeletal troponin I, troponin T, and beta-tropomyosin that cause distal arthrogryposis all increase contractile function.
por: Robinson, P, et al.
Publicado em: (2007)

Altered regulatory properties of human cardiac troponin I mutants that cause hypertrophic cardiomyopathy.
por: Elliott, K, et al.
Publicado em: (2000)

DCM troponin C mutant Gly159Asp blunts the response to troponin phosphorylation.
por: Preston, L, et al.
Publicado em: (2007)

Novel mutations in cardiac MYPBC3 cause early onset malignant hypertrophic cardiomyopathy (HCM)
por: Carballo, S, et al.
Publicado em: (2005)