Poly(ADP-ribose) polymerase-1 modulates DNA repair capacity and prevents formation of DNA double strand breaks.

Poly(ADP-ribose) polymerase-1 modulates DNA repair capacity and prevents formation of DNA double strand breaks.

Although poly(ADP-ribose) polymerase-1 (PARP-1) has no enzymatic activity involved in DNA damage processing by the base excision repair (BER) pathway, PARP-1 deficient cells are genetically unstable and sensitive to DNA-damaging agents. To explain this paradox, we investigated the impact of PARP-1 o...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Woodhouse, B, Dianova, I, Parsons, J, Dianov, G
स्वरूप:	Journal article
भाषा:	English
प्रकाशित:	2008

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