Crystal Structures of the p21-activated kinases PAK4, PAK5, and PAK6 reveal catalytic domain plasticity of active group II PAKs

p21-activated kinases have been classified into two groups based on their domain architecture. Group II PAKs (PAK4-6) regulate a wide variety of cellular functions, and PAK deregulation has been linked to tumor development. Structural comparison of five high-resolution structures comprising all acti...

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Dettagli Bibliografici
Autori principali:	Eswaran, J, Lee, W, Debreczeni, J, Filippakopoulos, P, Turnbull, A, Fedorov, O, Deacon, S, Peterson, J, Knapp, S
Natura:	Journal article
Lingua:	English
Pubblicazione:	Cell Press 2007
Soggetti:	Animals Catalytic Domain chemistry antagonists and inhibitors Protein Conformation Crystallography Protein-Serine-Threonine Kinases pharmacology Amino Acid Sequence Molecular Sequence Data Purines Protein Kinase Inhibitors genetics drug effects

Crystal Structures of the p21-activated kinases PAK4, PAK5, and PAK6 reveal catalytic domain plasticity of active group II PAKs. di Eswaran, J, Lee, W, Debreczeni, J, Filippakopoulos, P, Turnbull, A, Fedorov, O, Deacon, S, Peterson, JR, Knapp, S

Pubblicazione 2007

Journal article

Crystal Structures of the p21-activated kinases PAK4, PAK5, and PAK6 reveal catalytic domain plasticity of active group II PAKs

Crystal Structures of the p21-activated kinases PAK4, PAK5, and PAK6 reveal catalytic domain plasticity of active group II PAKs. di Eswaran, J, Lee, W, Debreczeni, J, Filippakopoulos, P, Turnbull, A, Fedorov, O, Deacon, S, Peterson, JR, Knapp, S

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