Crystal Structures of the p21-activated kinases PAK4, PAK5, and PAK6 reveal catalytic domain plasticity of active group II PAKs

p21-activated kinases have been classified into two groups based on their domain architecture. Group II PAKs (PAK4-6) regulate a wide variety of cellular functions, and PAK deregulation has been linked to tumor development. Structural comparison of five high-resolution structures comprising all acti...

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Main Authors:	Eswaran, J, Lee, W, Debreczeni, J, Filippakopoulos, P, Turnbull, A, Fedorov, O, Deacon, S, Peterson, J, Knapp, S
格式:	Journal article
语言:	English
出版:	Cell Press 2007
主题:	Animals Catalytic Domain chemistry antagonists and inhibitors Protein Conformation Crystallography Protein-Serine-Threonine Kinases pharmacology Amino Acid Sequence Molecular Sequence Data Purines Protein Kinase Inhibitors genetics drug effects

Crystal Structures of the p21-activated kinases PAK4, PAK5, and PAK6 reveal catalytic domain plasticity of active group II PAKs. 由 Eswaran, J, Lee, W, Debreczeni, J, Filippakopoulos, P, Turnbull, A, Fedorov, O, Deacon, S, Peterson, JR, Knapp, S

出版 2007

Journal article

Crystal Structures of the p21-activated kinases PAK4, PAK5, and PAK6 reveal catalytic domain plasticity of active group II PAKs

Crystal Structures of the p21-activated kinases PAK4, PAK5, and PAK6 reveal catalytic domain plasticity of active group II PAKs. 由 Eswaran, J, Lee, W, Debreczeni, J, Filippakopoulos, P, Turnbull, A, Fedorov, O, Deacon, S, Peterson, JR, Knapp, S

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