Crystal Structures of the p21-activated kinases PAK4, PAK5, and PAK6 reveal catalytic domain plasticity of active group II PAKs

Crystal Structures of the p21-activated kinases PAK4, PAK5, and PAK6 reveal catalytic domain plasticity of active group II PAKs

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p21-activated kinases have been classified into two groups based on their domain architecture. Group II PAKs (PAK4-6) regulate a wide variety of cellular functions, and PAK deregulation has been linked to tumor development. Structural comparison of five high-resolution structures comprising all acti...

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Dades bibliogràfiques
Autors principals: Eswaran, J, Lee, W, Debreczeni, J, Filippakopoulos, P, Turnbull, A, Fedorov, O, Deacon, S, Peterson, J, Knapp, S
Format: Journal article
Idioma:English
Publicat: Cell Press 2007
Matèries:
Animals
Catalytic Domain
chemistry
antagonists and inhibitors
Protein Conformation
Crystallography
Protein-Serine-Threonine Kinases
pharmacology
Amino Acid Sequence
Molecular Sequence Data
Purines
Protein Kinase Inhibitors
genetics
drug effects

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