Crystal Structures of the p21-activated kinases PAK4, PAK5, and PAK6 reveal catalytic domain plasticity of active group II PAKs

p21-activated kinases have been classified into two groups based on their domain architecture. Group II PAKs (PAK4-6) regulate a wide variety of cellular functions, and PAK deregulation has been linked to tumor development. Structural comparison of five high-resolution structures comprising all acti...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính:	Eswaran, J, Lee, W, Debreczeni, J, Filippakopoulos, P, Turnbull, A, Fedorov, O, Deacon, S, Peterson, J, Knapp, S
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	Cell Press 2007
Những chủ đề:	Animals Catalytic Domain chemistry antagonists and inhibitors Protein Conformation Crystallography Protein-Serine-Threonine Kinases pharmacology Amino Acid Sequence Molecular Sequence Data Purines Protein Kinase Inhibitors genetics drug effects

Crystal Structures of the p21-activated kinases PAK4, PAK5, and PAK6 reveal catalytic domain plasticity of active group II PAKs

Những quyển sách tương tự