Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease

Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease

Show other versions (2)

BACKGROUND-: The endothelial nitric oxide synthase cofactor tetrahydrobiopterin (BH4) plays a pivotal role in maintaining endothelial function in experimental vascular disease models and in humans. Augmentation of endogenous BH4 levels by oral BH4 treatment has been proposed as a potential therapeut...

Full description

Bibliographic Details
Main Authors: Cunnington, C, Van Assche, T, Shirodaria, C, Kylintireas, I, Lindsay, A, Lee, J, Antoniades, C, Margaritis, M, Lee, R, Cerrato, R, Crabtree, M, Francis, J, Sayeed, R, Ratnatunga, C, Pillai, R, Choudhury, R, Neubauer, S, Channon, K
Format: Journal article
Published: 2012
Show all versions (3)

Similar Items