A randomized 'blinded' comparison of two doses of antivenom in the treatment of Bothrops envenoming in Sao Paulo, Brazil.
An earlier study in São Paulo state suggested that the dose for patients with mild or moderate envenoming by Bothrops snakes (mainly Bothrops jararaca) could be effectively decreased to 4 ampoules (40 mL) of Brazilian Brothrops polyspecific antivenom. The present 'blinded' study examined t...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1995
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| _version_ | 1826265299282821120 |
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| author | Jorge, M Cardoso, J Castro, S Ribeiro, L França, F de Almeida, M Kamiguti, A Santo-Martins, I Santoro, M Mancau, J |
| author_facet | Jorge, M Cardoso, J Castro, S Ribeiro, L França, F de Almeida, M Kamiguti, A Santo-Martins, I Santoro, M Mancau, J |
| author_sort | Jorge, M |
| collection | OXFORD |
| description | An earlier study in São Paulo state suggested that the dose for patients with mild or moderate envenoming by Bothrops snakes (mainly Bothrops jararaca) could be effectively decreased to 4 ampoules (40 mL) of Brazilian Brothrops polyspecific antivenom. The present 'blinded' study examined the lowest dose studied in the first trial (equivalent to 4 x 10 mL ampoules) and half that dose of antivenom (equivalent to 2 x 10 mL ampoules) in 2 similar groups of 170 patients who were comparable in all respects before treatment. The majority of patients showed rapid clinical improvement after treatment with either dose regimen and rapid restoration of blood coagulability and cessation of bleeding. There was no apparent difference between the 2 groups of patients in any respect. The study confirmed that, in such patients, the dose of antivenom can be decreased from 4 ampoules to 2 ampoules without reduction of therapeutic efficacy, and it is highly likely that this reduction will result in a decrease of early anaphylactic reactions caused by the antivenom. |
| first_indexed | 2024-03-06T20:21:30Z |
| format | Journal article |
| id | oxford-uuid:2def8e4e-ca6a-4284-a7c5-6b0bb523e7c6 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:21:30Z |
| publishDate | 1995 |
| record_format | dspace |
| spelling | oxford-uuid:2def8e4e-ca6a-4284-a7c5-6b0bb523e7c62022-03-26T12:46:02ZA randomized 'blinded' comparison of two doses of antivenom in the treatment of Bothrops envenoming in Sao Paulo, Brazil.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2def8e4e-ca6a-4284-a7c5-6b0bb523e7c6EnglishSymplectic Elements at Oxford1995Jorge, MCardoso, JCastro, SRibeiro, LFrança, Fde Almeida, MKamiguti, ASanto-Martins, ISantoro, MMancau, JAn earlier study in São Paulo state suggested that the dose for patients with mild or moderate envenoming by Bothrops snakes (mainly Bothrops jararaca) could be effectively decreased to 4 ampoules (40 mL) of Brazilian Brothrops polyspecific antivenom. The present 'blinded' study examined the lowest dose studied in the first trial (equivalent to 4 x 10 mL ampoules) and half that dose of antivenom (equivalent to 2 x 10 mL ampoules) in 2 similar groups of 170 patients who were comparable in all respects before treatment. The majority of patients showed rapid clinical improvement after treatment with either dose regimen and rapid restoration of blood coagulability and cessation of bleeding. There was no apparent difference between the 2 groups of patients in any respect. The study confirmed that, in such patients, the dose of antivenom can be decreased from 4 ampoules to 2 ampoules without reduction of therapeutic efficacy, and it is highly likely that this reduction will result in a decrease of early anaphylactic reactions caused by the antivenom. |
| spellingShingle | Jorge, M Cardoso, J Castro, S Ribeiro, L França, F de Almeida, M Kamiguti, A Santo-Martins, I Santoro, M Mancau, J A randomized 'blinded' comparison of two doses of antivenom in the treatment of Bothrops envenoming in Sao Paulo, Brazil. |
| title | A randomized 'blinded' comparison of two doses of antivenom in the treatment of Bothrops envenoming in Sao Paulo, Brazil. |
| title_full | A randomized 'blinded' comparison of two doses of antivenom in the treatment of Bothrops envenoming in Sao Paulo, Brazil. |
| title_fullStr | A randomized 'blinded' comparison of two doses of antivenom in the treatment of Bothrops envenoming in Sao Paulo, Brazil. |
| title_full_unstemmed | A randomized 'blinded' comparison of two doses of antivenom in the treatment of Bothrops envenoming in Sao Paulo, Brazil. |
| title_short | A randomized 'blinded' comparison of two doses of antivenom in the treatment of Bothrops envenoming in Sao Paulo, Brazil. |
| title_sort | randomized blinded comparison of two doses of antivenom in the treatment of bothrops envenoming in sao paulo brazil |
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