Position-independent, high-level expression of the human beta-globin gene in transgenic mice.
We have constructed a "minilocus" that contains the 5' and 3' flanking regions of the human beta-globin locus and the beta-globin gene. These regions are characterized by erythroid-specific DNAase I-superhypersensitive sites and are normally located approximately 50 kb 5' an...
Main Authors: | Grosveld, F, van Assendelft, G, Greaves, D, Kollias, G |
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פורמט: | Journal article |
שפה: | English |
יצא לאור: |
1987
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פריטים דומים
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REGULATION OF EXPRESSION FROM THE HUMAN BETA-GLOBIN GENE DOMAIN
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The beta-globin dominant control region activates homologous and heterologous promoters in a tissue-specific manner.
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The beta-globin dominant control region.
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יצא לאור: (1989) -
A dominant control region from the human beta-globin locus conferring integration site-independent gene expression.
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